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dc.contributor.authorMu, W.
dc.contributor.authorLi, S.
dc.contributor.authorGuo, X.
dc.contributor.authorWu, H.
dc.contributor.authorChen, Z.
dc.contributor.authorQiao, L.
dc.contributor.authorHelfer, Gisela
dc.contributor.authorLu, F.
dc.contributor.authorLiu, C.
dc.contributor.authorWu, Q.-F.
dc.date.accessioned2021-05-12T13:23:04Z
dc.date.available2021-05-12T13:23:04Z
dc.date.issued2021-04-16
dc.identifier.citationMu W, Li S, Xu J et al (2021) Hypothalamic Rax(+) tanycytes contribute to tissue repair and tumorigenesis upon oncogene activation in mice. Nature Communications. 12: 2288.en_US
dc.identifier.urihttp://hdl.handle.net/10454/18459
dc.descriptionYesen_US
dc.description.abstractHypothalamic tanycytes in median eminence (ME) are emerging as a crucial cell population that regulates endocrine output, energy balance and the diffusion of blood-born molecules. Tanycytes have recently been considered as potential somatic stem cells in the adult mammalian brain, but their regenerative and tumorigenic capacities are largely unknown. Here we found that Rax+ tanycytes in ME of mice are largely quiescent but quickly enter the cell cycle upon neural injury for self-renewal and regeneration. Mechanistically, Igf1r signaling in tanycytes is required for tissue repair under injury conditions. Furthermore, Braf oncogenic activation is sufficient to transform Rax+ tanycytes into actively dividing tumor cells that eventually develop into a papillary craniopharyngioma-like tumor. Together, these findings uncover the regenerative and tumorigenic potential of tanycytes. Our study offers insights into the properties of tanycytes, which may help to manipulate tanycyte biology for regulating hypothalamic function and investigate the pathogenesis of clinically relevant tumors.en_US
dc.language.isoenen_US
dc.rights(c) 2021 The Authors. This is an Open Access article distributed under the Creative Commons CC-BY license (http://creativecommons.org/licenses/by/4.0/)en_US
dc.subjectTanycyteen_US
dc.subjectMedian eminenceen_US
dc.subjectHypothalamusen_US
dc.subjectTissue repairen_US
dc.subjectTumorigenesisen_US
dc.subjectStem cellsen_US
dc.titleHypothalamic Rax+ tanycytes contribute to tissue repair and tumorigenesis upon oncogene activation in miceen_US
dc.status.refereedYesen_US
dc.date.Accepted2021-03-22
dc.typeArticleen_US
dc.type.versionPublished versionen_US
dc.identifier.doihttps://doi.org/10.1038/s41467-021-22640-z
refterms.dateFOA2021-05-12T13:23:27Z
dc.openaccess.statusGolden_US


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