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dc.contributor.authorGülçür, Mert,
dc.contributor.authorRomano, J-M.
dc.contributor.authorPenchev, P.
dc.contributor.authorGough, Timothy D.
dc.contributor.authorBrown, Elaine C.
dc.contributor.authorDimov, S.
dc.contributor.authorWhiteside, Benjamin R.
dc.date.accessioned2021-04-08T14:52:43Z
dc.date.accessioned2021-04-22T11:28:58Z
dc.date.available2021-04-08T14:52:43Z
dc.date.available2021-04-22T11:28:58Z
dc.date.issued2021-01
dc.identifier.citationGülçür M, Romano J-M, Penchev P (2021) A cost-effective process chain for thermoplastic microneedle manufacture combining laser micro-machining and micro-injection moulding. CIRP Journal of Manufacturing Science and Technology. 32: 311-321.en_US
dc.identifier.urihttp://hdl.handle.net/10454/18446
dc.descriptionYesen_US
dc.description.abstractHigh-throughput manufacturing of transdermal microneedle arrays poses a significant challenge due to the high precision and number of features that need to be produced and the requirement of multi-step processing methods for achieving challenging micro-features. To address this challenge, we report a flexible and cost-effective process chain for transdermal microneedle array manufacture that includes mould production using laser machining and replication of thermoplastic microneedles via micro-injection moulding (micromoulding). The process chain also incorporates an in-line manufacturing data monitoring capability where the variability in the quality of microneedle arrays can be determined in a production run using captured data. Optical imaging and machine vision technologies are also implemented to create a quality inspection system that allows rapid evaluation of key quality indicators. The work presents the capability of laser machining as a cost-effective method for making microneedle moulds and micro-injection moulding of thermoplastic microneedle arrays as a highly-suitable manufacturing technique for large-scale production with low marginal cost.en_US
dc.description.sponsorshipThis research work was undertaken in the context of MICRO-MAN project (“Process Fingerprint for Zero-defect Net-shapeMICROMANufacturing”, http://www.microman.mek.dtu.dk/).MICROMAN is a European Training Network supported byHorizon 2020, the EU Framework Programme for Research andInnovation (Project ID: 674801). This research has also receivedfunding and support from two other Horizon 2020 projects:HIMALAIA (Grant agreement No. 766871) and Laser4Fun (GA no.675063).en_US
dc.language.isoenen_US
dc.publisherElsevier
dc.rights© 2021 CIRP. Reproduced in accordance with the publisher's self-archiving policy. This manuscript version is made available under the CC-BY-NC-ND 4.0 license.en_US
dc.subjectMicroneedle arraysen_US
dc.subjectMicro-injection moldingen_US
dc.subjectLaser micro-machiningen_US
dc.subjectProcess monitoringen_US
dc.subjectData acquisitionen_US
dc.subjectPolymer replicationen_US
dc.titleA cost-effective process chain for thermoplastic microneedle manufacture combining laser micro-machining and micro-injection mouldingen_US
dc.status.refereedYesen_US
dc.date.application2021-02-04
dc.typeArticleen_US
dc.type.versionAccepted manuscripten_US
dc.identifier.doihttps://doi.org/10.1016/j.cirpj.2021.01.015
dc.date.updated2021-04-08T13:53:10Z
refterms.dateFOA2021-04-22T11:29:58Z
dc.openaccess.statusGreenen_US


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