Synthesis of sulfonamide-based ynamides and ynamines in water

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Publication date
2021-01
End of Embargo
2021-12-23
Author
Zhao, L.
Yang, H.
Li, R.
Tao, Y.
Guo, X-F.
Anderson, E.A.
Whiting, A.
Wu, Na (Anna)
Keyword
Ynamides
Ynamines
Water
Synthesis
Rights
© 2020 American Chemical Society. This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of Organic Chemistry, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.joc.0c02326.
Peer-Reviewed
Yes
Open Access status
Green

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Abstract
Ynamides, though relatively more stable than ynamines, are still moisture-sensitive and prone to hydration especially under acidic and heating conditions. Here we report an environmentally benign, robust protocol to synthesize sulfonamide-based ynamides and arylynamines via Sonogashira coupling reactions in water, using a readily available quaternary ammonium salt as the surfactant.
URI
http://hdl.handle.net/10454/18428
Version
Accepted manuscript
Citation
Zhao L, Yang H, Li r et al (2021) Synthesis of sulfonamide-based ynamides and ynamines in water. Journal of Organic Chemistry. 86(2): 1938-1947.
Link to publisher’s version
https://doi.org/10.1021/acs.joc.0c02326
Type
Article
Notes
The full-text of this article will be released for public view at the end of the publisher embargo on 23 Dec 2021.
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