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dc.contributor.authorPitto-Barry, Anaïs
dc.date.accessioned2021-03-23T09:42:26Z
dc.date.accessioned2021-03-31T15:17:53Z
dc.date.available2021-03-23T09:42:26Z
dc.date.available2021-03-31T15:17:53Z
dc.date.issued2021
dc.identifier.citationPitto-Barry A (2021) Polymers and boron neutron capture therapy(BNCT): a potent combination. Polymer Chemistry. Accepted for Publication.en_US
dc.identifier.urihttp://hdl.handle.net/10454/18415
dc.descriptionYesen_US
dc.description.abstractBoron neutron capture therapy (BNCT) has a long history of unfulfilled promises for the treatment of aggressive cancers. In the last two decades, chemists, physicists, and clinical scientists have been coordinating their efforts to overcome practical and scientific challenges needed to unlock its full therapeutic potential. From a chemistry point of view, the two current small-molecule drugs used in the clinic were developed in the 1950s, however, they both lack some of the essential requirements for making BNCT a successful therapeutic modality. Novel strategies are currently used to design new drugs, more selective towards cancer cells and tumours, as well as able to deliver high boron contents to the target. In this context, macromolecules, including polymers, are promising tools to make BNCT an effective, accepted, and front-line therapy against cancer. In this review, we will provide a brief overview of BNCT, and its potential and challenges, and we will discuss the most promising strategies that have been developed so far.en_US
dc.language.isoenen_US
dc.publisherRoyal Society of Chemistry
dc.relation.isreferencedbyhttps://doi.org/10.1039/D0PY01392Gen_US
dc.rightsOpen Access Article. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (https://creativecommons.org/licenses/by/3.0/).en_US
dc.subjectPolymeren_US
dc.subjectBoron neutron capture therapy (BNCT)en_US
dc.subjectCancer treatmenten_US
dc.titlePolymers and boron neutron capture therapy(BNCT): a potent combinationen_US
dc.status.refereedYesen_US
dc.date.Accepted2021-02-08
dc.date.application2021-03-23
dc.typeArticleen_US
dc.type.versionPublished versionen_US
dc.date.updated2021-03-23T09:42:37Z
refterms.dateFOA2021-03-31T15:18:52Z
dc.openaccess.statusGolden_US


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