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    Polymers and boron neutron capture therapy(BNCT): a potent combination

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    Pitto-Barry_Polymer_Chemistry (2.217Mb)
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    Publication date
    2021-03
    Author
    Pitto-Barry, Anaïs
    Keyword
    Polymer
    Boron neutron capture therapy (BNCT)
    Cancer treatment
    Rights
    Open Access Article. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (https://creativecommons.org/licenses/by/3.0/).
    Peer-Reviewed
    Yes
    Open Access status
    Gold
    
    Metadata
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    Abstract
    Boron neutron capture therapy (BNCT) has a long history of unfulfilled promises for the treatment of aggressive cancers. In the last two decades, chemists, physicists, and clinical scientists have been coordinating their efforts to overcome practical and scientific challenges needed to unlock its full therapeutic potential. From a chemistry point of view, the two current small-molecule drugs used in the clinic were developed in the 1950s, however, they both lack some of the essential requirements for making BNCT a successful therapeutic modality. Novel strategies are currently used to design new drugs, more selective towards cancer cells and tumours, as well as able to deliver high boron contents to the target. In this context, macromolecules, including polymers, are promising tools to make BNCT an effective, accepted, and front-line therapy against cancer. In this review, we will provide a brief overview of BNCT, and its potential and challenges, and we will discuss the most promising strategies that have been developed so far.
    URI
    http://hdl.handle.net/10454/18415
    Version
    Published version
    Citation
    Pitto-Barry A (2021) Polymers and boron neutron capture therapy(BNCT): a potent combination. Polymer Chemistry. 12(14): 2035-2044.
    Link to publisher’s version
    https://doi.org/10.1039/D0PY01392G
    Type
    Article
    Collections
    Life Sciences Publications

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