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dc.contributor.authorIzadyari Aghmiuni, A.
dc.contributor.authorHeidari Keshel, S.
dc.contributor.authorSefat, Farshid
dc.contributor.authorAkbarzadeh Khiyavi, A.
dc.date.accessioned2021-02-22T13:34:35Z
dc.date.accessioned2021-03-08T15:05:28Z
dc.date.available2021-02-22T13:34:35Z
dc.date.available2021-03-08T15:05:28Z
dc.date.issued2020-01
dc.identifier.citationIzadyari Aghmiuni A, Heidari Keshel S, Sefat F et al (2020) Quince seed mucilage-based scaffold as a smart biological substrate to mimic mechanobiological behavior of skin and promote fibroblasts proliferation and h-ASCs differentiation into keratinocytes. International Journal of Biological Macromolecules. 142: 668-679.en_US
dc.identifier.urihttp://hdl.handle.net/10454/18388
dc.descriptionYesen_US
dc.description.abstractThe use of biological macromolecules like quince seed mucilage (QSM), as the common curative practice has a long history in traditional folk medicine to cure wounds and burns. However, this gel cannot be applied on exudative wounds because of the high water content and non-absorption of infection of open wounds. It also limits cell-to-cell interactions and leads to the slow wound healing process. In this study to overcome these problems, a novel QSM-based hybrid scaffold modified by PCL/PEG copolymer was designed and characterized. The properties of this scaffold (PCL/QSM/PEG) were also compared with four scaffolds of PCL/PEG, PCL/Chitosan/PEG, chitosan, and QSM, to assess the role of QSM and the combined effect of polymers in improving the function of skin tissue-engineered scaffolds. It was found, the physicochemical properties play a crucial role in regulating cell behaviors so that, PCL/QSM/PEG as a smart/stimuli-responsive bio-matrix promotes not only human-adipose stem cells (h-ASCs) adhesion but also supports fibroblasts growth, via providing a porous-network. PCL/QSM/PEG could also induce keratinocytes at a desirable level for wound healing, by increasing the mechanobiological signals. Immunocytochemistry analysis confirmed keratinocytes differentiation pattern and their normal phenotype on PCL/QSM/PEG. Our study demonstrates, QSM as a differentiation/growth-promoting biological factor can be a proper candidate for design of wound dressings and skin tissue-engineered substrates containing cell.en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttps://doi.org/10.1016/j.ijbiomac.2019.10.008en_US
dc.rights© 2019 Elsevier B.V. All rights reserved. Reproduced in accordance with the publisher's self-archiving policy. This manuscript version is made available under the CC-BY-NC-ND 4.0 license.
dc.subjectBiological macromoleculesen_US
dc.subjectQuince seed mucilageen_US
dc.subjectSkin tissue-engineered scaffoldsen_US
dc.titleQuince seed mucilage-based scaffold as a smart biological substrate to mimic mechanobiological behavior of skin and promote fibroblasts proliferation and h-ASCs differentiation into keratinocytesen_US
dc.status.refereedYesen_US
dc.date.Accepted2019-10-01
dc.date.application2019-10-14
dc.typeArticleen_US
dc.type.versionAccepted manuscripten_US
dc.date.updated2021-02-22T13:34:38Z
refterms.dateFOA2021-03-08T15:38:19Z
dc.openaccess.statusGreenen_US


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