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dc.contributor.authorDeng, X.
dc.contributor.authorHuang, B.
dc.contributor.authorWang, Q.
dc.contributor.authorWu, W.
dc.contributor.authorCoates, Philip D.
dc.contributor.authorSefat, Farshid
dc.contributor.authorLu, C.
dc.contributor.authorZhang, W.
dc.contributor.authorZhang, X.
dc.date.accessioned2021-02-22T13:26:05Z
dc.date.accessioned2021-03-08T11:56:36Z
dc.date.available2021-02-22T13:26:05Z
dc.date.available2021-03-08T11:56:36Z
dc.date.issued2021-03
dc.identifier.citationDeng X, Huang B, Wang Q et al (2021) Mussel-inspired antibacterial hydrogel with high cell affinity, toughness, self-healing and recycling properties for wound healing. ACS Sustainable Chemistry and Engineering. 9(8): 3070-3082.en_US
dc.identifier.urihttp://hdl.handle.net/10454/18387
dc.descriptionYesen_US
dc.description.abstractAntibacterial hydrogels have been intensively studied due to their wide practical potential in wound healing. However, developing an antibacterial hydrogel that is able to integrate with exceptional mechanical properties, cell affinity, and adhesiveness will remain a major challenge. Herein, a novel hydrogel with antibacterial and superior biocompatibility properties was developed using aluminum ions (Al3+) and alginate− dopamine (Alg-DA) chains to cross-link with the copolymer chains of acrylamide and acrylic acid (PAM) via triple dynamic noncovalent interactions, including coordination, electrostatic interaction, and hydrogen bonding. The cationized nanofibrillated cellulose (CATNFC), which was synthesized by the grafting of long-chain quaternary ammonium salts onto nanofibrillated cellulose (NFC), was utilized innovatively in the preparation of antibacterial hydrogels. Meanwhile, alginate-modified dopamine (Alg-DA) was prepared from dopamine (DA) and alginate. Within the hydrogel, the catechol groups of Alg-DA provided a decent fibroblast cell adhesion to the hydrogel. Additionally, the multitype cross-linking structure within the hydrogel rendered the outstanding mechanical properties, self-healing ability, and recycling in pollution-free ways. The antibacterial test in vitro, cell affinity, and wound healing proved that the as-prepared hydrogel was a potential material with all-around performances in both preventing bacterial infection and promoting tissue regeneration during wound healing processes.en_US
dc.description.sponsorshipThis work was supported by the National Natural Science Foundation of China (32070826 and 51861165203), the Chinese Postdoctoral Science Foundation (2019M650239, 2020T130762), the Sichuan Science and Technology Program (2019YJ0125), the State Key Laboratory of Polymer Materials Engineering (sklpme2019-2-19), the Chongqing Research Program of Basic Research and Frontier Technology (cstc2018jcyjAX0807), Chongqing Medical Joint Research Project of Chongqing Science and Technology Committee & Health Agency (2020GDRC017), and the RCUK China-UK Science Bridges Program through the Medical Research Council, and the Fundamental Research Funds for the Central Universities.en_US
dc.language.isoenen_US
dc.publisherACS PUBLICATION
dc.relation.isreferencedbyhttps://doi.org/10.1021/acssuschemeng.0c06672en_US
dc.rights© 2020 ACS. This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Sustainable Chemistry and Engineering, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acssuschemeng.0c06672.
dc.subjectAntibacterial hydrogelen_US
dc.subjectCationized nanofibrillated cellulose (CATNFC)en_US
dc.subjectAlginate-dopamine (Alg-DA)en_US
dc.subjectSelf-healingen_US
dc.subjectWound-healingen_US
dc.titleA mussel-inspired antibacterial hydrogel with high cell affinity, toughness, self-healing, and recycling properties for wound healingen_US
dc.status.refereedYesen_US
dc.date.Accepted2021-01
dc.date.application2021-02-12
dc.typeArticleen_US
dc.date.EndofEmbargo2022-02-12
dc.type.versionAccepted manuscripten_US
dc.description.publicnotesThe full-text of this article will be released for public view at the end of the publisher embargo on 12 Feb 2022..
dc.date.updated2021-02-22T13:26:12Z
refterms.dateFOA2021-03-08T12:25:25Z
dc.openaccess.statusGreenen_US


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