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dc.contributor.authorClayton, R.W.
dc.contributor.authorLangan, E.A.
dc.contributor.authorAnsell, David M.
dc.contributor.authorde Vos, I.J.H.M.
dc.contributor.authorGöbel, K.
dc.contributor.authorSchneider, M.R.
dc.contributor.authorPicardo, M.
dc.contributor.authorLim, X.
dc.contributor.authorvan Steensel, M.A.M.
dc.contributor.authorPaus, R.
dc.date.accessioned2021-02-15T10:38:55Z
dc.date.accessioned2021-02-16T12:05:32Z
dc.date.available2021-02-15T10:38:55Z
dc.date.available2021-02-16T12:05:32Z
dc.date.issued2020-06
dc.identifier.citationClayton RW, Langan EA, Ansell DM et al (2020) Neuroendocrinology and neurobiology of sebaceous glands. Biological Reviews. 95(3): 592-624.en_US
dc.identifier.urihttp://hdl.handle.net/10454/18341
dc.descriptionNoen_US
dc.description.abstractThe nervous system communicates with peripheral tissues through nerve fibres and the systemic release of hypothalamic and pituitary neurohormones. Communication between the nervous system and the largest human organ, skin, has traditionally received little attention. In particular, the neuro-regulation of sebaceous glands (SGs), a major skin appendage, is rarely considered. Yet, it is clear that the SG is under stringent pituitary control, and forms a fascinating, clinically relevant peripheral target organ in which to study the neuroendocrine and neural regulation of epithelia. Sebum, the major secretory product of the SG, is composed of a complex mixture of lipids resulting from the holocrine secretion of specialised epithelial cells (sebocytes). It is indicative of a role of the neuroendocrine system in SG function that excess circulating levels of growth hormone, thyroxine or prolactin result in increased sebum production (seborrhoea). Conversely, growth hormone deficiency, hypothyroidism, and adrenal insufficiency result in reduced sebum production and dry skin. Furthermore, the androgen sensitivity of SGs appears to be under neuroendocrine control, as hypophysectomy (removal of the pituitary) renders SGs largely insensitive to stimulation by testosterone, which is crucial for maintaining SG homeostasis. However, several neurohormones, such as adrenocorticotropic hormone and α-melanocyte-stimulating hormone, can stimulate sebum production independently of either the testes or the adrenal glands, further underscoring the importance of neuroendocrine control in SG biology. Moreover, sebocytes synthesise several neurohormones and express their receptors, suggestive of the presence of neuro-autocrine mechanisms of sebocyte modulation. Aside from the neuroendocrine system, it is conceivable that secretion of neuropeptides and neurotransmitters from cutaneous nerve endings may also act on sebocytes or their progenitors, given that the skin is richly innervated. However, to date, the neural controls of SG development and function remain poorly investigated and incompletely understood. Botulinum toxin-mediated or facial paresis-associated reduction of human sebum secretion suggests that cutaneous nerve-derived substances modulate lipid and inflammatory cytokine synthesis by sebocytes, possibly implicating the nervous system in acne pathogenesis. Additionally, evidence suggests that cutaneous denervation in mice alters the expression of key regulators of SG homeostasis. In this review, we examine the current evidence regarding neuroendocrine and neurobiological regulation of human SG function in physiology and pathology. We further call attention to this line of research as an instructive model for probing and therapeutically manipulating the mechanistic links between the nervous system and mammalian skin.en_US
dc.description.sponsorshipAgency for Science, Technology and Research. Grant Numbers: A*STAR Research Attachment Programme (ARAP), IAF‐PP H17/01/a0/004, IAF‐PP H17/01/a0/008; NIHR Manchester Biomedical Research Centre, Inflammatory Hair Disease Programme; University of Manchester; University of Miamien_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttps://doi.org/10.1111/brv.12579en_US
dc.subjectAcne vulgarisen_US
dc.subjectAndrogensen_US
dc.subjectHormonesen_US
dc.subjectNervous systemen_US
dc.subjectNeuroendocrinologyen_US
dc.subjectNeuronsen_US
dc.subjectNeuropeptidesen_US
dc.subjectSebaceous glanden_US
dc.subjectSebumen_US
dc.subjectSkinen_US
dc.titleNeuroendocrinology and neurobiology of sebaceous glandsen_US
dc.status.refereedYesen_US
dc.date.Accepted2019-12-19
dc.date.application2020-01-22
dc.typeArticleen_US
dc.type.versionNo full-text in the repositoryen_US
dc.date.updated2021-02-15T10:39:12Z
refterms.dateFOA2021-02-16T12:08:34Z
dc.openaccess.statusNot Open Accessen_US


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