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dc.contributor.authorWandel, M.B.
dc.contributor.authorBell, C.A.
dc.contributor.authorYu, J.
dc.contributor.authorArno, M.C.
dc.contributor.authorDreger, N.Z.
dc.contributor.authorHsu, Y.-H.
dc.contributor.authorPitto-Barry, Anaïs
dc.contributor.authorWorch, J.C.
dc.contributor.authorDove, A.P.
dc.contributor.authorBecker, M.L.
dc.date.accessioned2020-12-17T15:50:03Z
dc.date.available2020-12-17T15:50:03Z
dc.date.issued2021-01-19
dc.identifier.citationWandel MB, Bell CA, Yu J et al (2021) Concomitant Control of Mechanical Properties and Degradation in Resorbable Elastomer-like Materials Using Stereochemistry and Stoichiometry for Soft Tissue Engineering. Nature Communications. 12: 446.en_US
dc.identifier.urihttp://hdl.handle.net/10454/18245
dc.descriptionYesen_US
dc.description.abstractComplex biological tissues are highly viscoelastic and dynamic. Efforts to repair or replace cartilage, tendon, muscle, and vasculature using materials that facilitate repair and regeneration have been ongoing for decades. However, materials that possess the mechanical, chemical and resorption characteristics necessary to recapitulate these tissues have been difficult to mimic using synthetic resorbable biomaterials. Herein, we report a series of resorbable elastomer-like materials that are compositionally identical and possess varying ratios of cis:trans double bonds in the backbone. These features afford concomitant control over the mechanical and surface eroding degradation properties of these materials. We show the materials can be functionalized post-polymerization with bioactive species and enhance cell adhesion. Furthermore, an in vivo rat model demonstrates that degradation and resorption are dependent on succinate stoichiometry in the elastomers and the results show limited inflammation highlighting their potential for use in soft tissue regeneration and drug delivery.en_US
dc.language.isoenen_US
dc.rights(c) 2021 The Authors. This is an Open Access article distributed under the Creative Commons CC-BY license (https://creativecommons.org/licenses/by/4.0/legalcode)en_US
dc.subjectElastomeren_US
dc.subjectMechanical propertiesen_US
dc.subjectSoft tissue engineeringen_US
dc.subjectDegradable materialen_US
dc.titleConcomitant Control of Mechanical Properties and Degradation in Resorbable Elastomer-like Materials Using Stereochemistry and Stoichiometry for Soft Tissue Engineeringen_US
dc.status.refereedYesen_US
dc.date.Accepted2020-12-07
dc.typeArticleen_US
dc.type.versionAccepted manuscripten_US
dc.identifier.doihttps://doi.org/10.1038/s41467-020-20610-5
refterms.dateFOA2020-12-17T15:50:34Z


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