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dc.contributor.authorClark, D.W.
dc.contributor.authorOkada, Y.
dc.contributor.authorMoore, K.H.S.
dc.contributor.authorMason, D.
dc.contributor.authorPirastu, N.
dc.contributor.authorGandin, I.
dc.contributor.authorMattsson, H.
dc.contributor.authorBarnes, C.L.K.
dc.contributor.authorLin, K.
dc.contributor.authorZhao, J.H.
dc.contributor.authorDeelan, P.
dc.contributor.authorRohde, R.
dc.contributor.authorSchurmann, C.
dc.contributor.authorGuo, X.
dc.contributor.authorGiulianini, F.
dc.contributor.authorZhang, W.
dc.contributor.authorMedina-Gomez, C.
dc.contributor.authorKarlsson, R.
dc.contributor.authorBao, Y.
dc.contributor.authorBartz, T.M.
dc.contributor.authorBaumbach, C.
dc.contributor.authorBiino, G.
dc.contributor.authorBixley, M.J.
dc.contributor.authorBrumat, M.
dc.contributor.authorChai, J.F.
dc.contributor.authorCorre, T.
dc.contributor.authorCousminer, D.L.
dc.contributor.authorDekker, A.M.
dc.contributor.authorEccles, D.A.
dc.contributor.authorvan Eijk, K.R.
dc.contributor.authorFuchsberger, C.
dc.contributor.authorGao, H.
dc.contributor.authorGermain, M.
dc.contributor.authorGordon, S.D.
dc.contributor.authorde Haan, H.G.
dc.contributor.authorHarris, S.E.
dc.contributor.authorHofer, E.
dc.contributor.authorHuerta-Chagoya, A.
dc.contributor.authorIgartua, C.
dc.contributor.authorJansen, I.E.
dc.contributor.authorJia, Y.
dc.contributor.authorKacprowski, T.
dc.contributor.authorKarlsson, T.
dc.contributor.authorKleber, M.E.
dc.contributor.authorLi, S.A.
dc.contributor.authorLi-Gao, R.
dc.contributor.authorMahajan, A.
dc.contributor.authorMatsuda, K.
dc.contributor.authorMeidtner, K.
dc.contributor.authorMeng, W.
dc.contributor.authorMontasser, M.E.
dc.contributor.authorvan der Most, P.J.
dc.contributor.authorMunz, M.
dc.contributor.authorNutile, T.
dc.contributor.authorPalviainen, T.
dc.contributor.authorPrasad, G.
dc.contributor.authorPrasad, R.B.
dc.contributor.authorPriyanka, T.D.S.
dc.contributor.authorRizzi, F.
dc.contributor.authorSalvi, E.
dc.contributor.authorSapkota, B.R.
dc.contributor.authorShriner, D.
dc.contributor.authorSkotte, L.
dc.contributor.authorSmart, M.C.
dc.contributor.authorSmith, A.V.
dc.contributor.authorvan der Spek, A.
dc.contributor.authorSpracklen, C.N.
dc.contributor.authorStrawbridge, R.J.
dc.contributor.authorTajuddin, S.M.
dc.contributor.authorTrompet, S.
dc.contributor.authorTurman, C.
dc.contributor.authorVerweij, N.
dc.contributor.authorViberti, C.
dc.contributor.authorWang, L.
dc.contributor.authorWarren, H.R.
dc.contributor.authorWootton, R.E.
dc.contributor.authorYanek, L.R.
dc.contributor.authorYao, J.
dc.contributor.authorYousri, N.A.
dc.contributor.authorZhao, W.
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dc.contributor.authorToniolo, D.
dc.contributor.authorTregouet, D.-A.
dc.contributor.authorTuomi, T.
dc.contributor.authorVollenweider, P.
dc.contributor.authorWang, C.A.
dc.contributor.authorWeir, D.R.
dc.contributor.authorWhitfield, J.B.
dc.contributor.authorWijmenga C.
dc.contributor.authorWng, T.-Y.
dc.contributor.authorWright, J.
dc.contributor.authorYang, J.
dc.contributor.authorYu, L.
dc.contributor.authorZemel, B.S.
dc.contributor.authorZonderman, A.B.
dc.contributor.authorPerola, M.
dc.contributor.authorMagnusson, P.K.E.
dc.contributor.authorUitterlinden, A.G.
dc.contributor.authorKooner, J.S.
dc.contributor.authorChasman, D.I.
dc.contributor.authorLoos, R.J.F.
dc.contributor.authorFranceschini, N.
dc.contributor.authorFranke, L.
dc.contributor.authorHaley, C.S.
dc.contributor.authorHayward, C.
dc.contributor.authorWalters, R.G.
dc.contributor.authorPerry, J.R.B.
dc.contributor.authorEsko, T.
dc.contributor.authorHelgason, A.
dc.contributor.authorStefansson, K.
dc.contributor.authorJoshi, P.K.
dc.contributor.authorKubo, M.
dc.contributor.authorWilson, J.F.
dc.date.accessioned2020-11-28T15:58:39Z
dc.date.accessioned2020-12-09T11:28:55Z
dc.date.available2020-11-28T15:58:39Z
dc.date.available2020-12-09T11:28:55Z
dc.date.issued2019-10
dc.identifier.citationClark DW, Okada Y, Moore KHS, et al. (2019) Associations of autozygosity with a broad range of human phenotypes. Nature Communications. 10(1): 4957en_US
dc.identifier.urihttp://hdl.handle.net/10454/18210
dc.descriptionyesen_US
dc.description.abstractIn many species, the offspring of related parents suffer reduced reproductive success, a phenomenon known as inbreeding depression. In humans, the importance of this effect has remained unclear, partly because reproduction between close relatives is both rare and frequently associated with confounding social factors. Here, using genomic inbreeding coefficients (FROH) for >1.4 million individuals, we show that FROH is significantly associated (p < 0.0005) with apparently deleterious changes in 32 out of 100 traits analysed. These changes are associated with runs of homozygosity (ROH), but not with common variant homozygosity, suggesting that genetic variants associated with inbreeding depression are predominantly rare. The effect on fertility is striking: FROH equivalent to the offspring of first cousins is associated with a 55% decrease [95% CI 44–66%] in the odds of having children. Finally, the effects of FROH are confirmed within full-sibling pairs, where the variation in FROH is independent of all environmental confounding.en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttps://doi.org/10.1038/s41467-019-12283-6en_US
dc.rights© 2019, The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License.en_US
dc.subjectConsanguinityen_US
dc.subjectGenetic association studyen_US
dc.subjectGenetic markersen_US
dc.subjectInbreedingen_US
dc.subjectInbreeding depressionen_US
dc.titleAssociations of autozygosity with a broad range of human phenotypesen_US
dc.status.refereedyesen_US
dc.date.Accepted2019-08-30
dc.typeArticleen_US
dc.type.versionPublished versionen_US
dc.date.updated2020-11-28T15:58:40Z
refterms.dateFOA2020-12-09T11:29:35Z


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