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dc.contributor.authorRibeiro Morais, Goreti
dc.contributor.authorFalconer, Robert A.
dc.date.accessioned2020-11-16T13:41:41Z
dc.date.accessioned2020-11-20T12:29:39Z
dc.date.available2020-11-16T13:41:41Z
dc.date.available2020-11-20T12:29:39Z
dc.date.issued2020
dc.identifier.citationRibeiro Morais G and Falconer RA (2020) Glycosyl disulfides: importance, synthesis and application to chemical and biological systems. Organic and Biomolecular Chemistry. Accepted for Publication.en_US
dc.identifier.urihttp://hdl.handle.net/10454/18174
dc.descriptionYesen_US
dc.description.abstractThe disulfide bond plays an important role in the formation and stabilisation of higher order structures of peptides and proteins, while in recent years interest in this functional group has been extended to carbohydrate chemistry. Rarely found in nature, glycosyl disulfides have attracted significant attention as glycomimetics, with wide biological applications including lectin binding, as key components of dynamic libraries to study carbohydrate structures, the study of metabolic and enzymatic studies, and even as potential drug molecules. This interest has been accompanied and fuelled by the continuous development of new methods to construct the disulfide bond at the anomeric centre. Glycosyl disulfides have also been exploited as versatile intermediates in carbohydrate synthesis, particularly as glycosyl donors. This review focuses on the importance of the disulfide bond in glycobiology and in chemistry, evaluating the different methods available to synthesise glycosyl disulfides. Furthermore, we review the role of glycosyl disulfides as intermediates and/or glycosyl donors for the synthesis of neoglycoproteins and oligosaccharides, before finally considering examples of how this important class of carbohydrates have made an impact in biological and therapeutic contexts.en_US
dc.description.sponsorshipThe authors thank the Institute of Cancer Therapeutics (University of Bradford) Doctoral Training Centre for financial support.en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttps://doi.org/10.1039/D0OB02079Fen_US
dc.rights© The Royal Society of Chemistry 2020. This article is Open Access, licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence (https://creativecommons.org/licenses/by-nc/3.0/).en_US
dc.subjectGlycosyl disulfidesen_US
dc.subjectCarbohydrate chemistryen_US
dc.subjectDisulfide bondsen_US
dc.subjectGlycobiologyen_US
dc.titleGlycosyl disulfides: importance, synthesis and application to chemical and biological systemsen_US
dc.status.refereedYesen_US
dc.date.Accepted2020-11-10
dc.date.application2020-11-10
dc.typeArticleen_US
dc.type.versionPublished versionen_US
dc.date.updated2020-11-16T13:41:54Z
refterms.dateFOA2020-11-20T12:30:18Z


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