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    Evaluation of the toxicity of two electron-deficient half-sandwich complexes against human lymphocytes from healthy individuals

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    Publication date
    2021-02
    End of Embargo
    2021-10-30
    Author
    Habas, Khaled S.A.
    Soldevila Barreda, Joan J.
    Azmanova, Maria
    Rafols, Laia
    Pitto-Barry, Anaïs
    Anderson, Diana
    Barry, Nicolas P.E.
    Keyword
    Half-sandwich complexes
    Electron-deficient organometallics
    Bioinorganic chemistry
    Lymphocytes
    Anticancer metallodrugs
    Rights
    © 2020 Wiley‐VCH GmbH. This is the peer reviewed version of the following article: Habas K, Soldevila Barreda JJ, Azmanova M et al (2020) Evaluation of the toxicity of two electron-deficient half-sandwich complexes against human lymphocytes from healthy individuals. ChemMedChem. 16(4): 624-629, which has been published in final form at https://doi.org/10.1002/cmdc.202000672. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
    Peer-Reviewed
    Yes
    
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    Abstract
    Electron‐deficient half‐sandwich complexes are a class of under‐studied organometallics with demonstrated potential as metallodrug candidates. The present study investigates the effect of two 16‐electron organoruthenium complexes ([( p‐ cym)Ru(benzene‐1,2‐dithiolato)] ( 1 ) and [( p ‐cym)Ru(maleonitriledithiolate)] ( 2 )) on the cell viability of non‐immortalised human lymphocytes from healthy individuals. The genotoxic effects of 1 and 2 in lymphocytes using the Comet and cytokinesis‐block micronucleus assays is also investigated. Gene expression studies were carried out on a panel of genes involved in apoptosis and DNA damage repair response. Results show that the two 16‐electron complexes do not have significant effect on the cell viability of human lymphocytes from healthy individuals. However, an increase in DNA damage is induced by both compounds, presumably through oxidative stress production.
    URI
    http://hdl.handle.net/10454/18162
    Version
    Accepted manuscript
    Citation
    Habas K, Soldevila Barreda JJ, Azmanova M et al (2021) Evaluation of the toxicity of two electron-deficient half-sandwich complexes against human lymphocytes from healthy individuals. ChemMedChem. 16(4): 624-629.
    Link to publisher’s version
    https://doi.org/10.1002/cmdc.202000672
    Type
    Article
    Notes
    The full-text of this article will be released for public view at the end of the publisher embargo on 30 Oct 2021.
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    Life Sciences Publications

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