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dc.contributor.authorBrahmbhatt, H.A.
dc.contributor.authorSurtees, Alexander P.H.
dc.contributor.authorTierney, C.
dc.contributor.authorIge, O.A.
dc.contributor.authorPiletska, E.V.
dc.contributor.authorSwift, Thomas
dc.contributor.authorTurner, N.W.
dc.date.accessioned2020-10-14T08:48:03Z
dc.date.accessioned2020-10-28T09:36:03Z
dc.date.available2020-10-14T08:48:03Z
dc.date.available2020-10-28T09:36:03Z
dc.date.issued2020-08
dc.identifier.citationBrahmbhatt HA, Surtees A, Tierney C et al (2020) Effect of polymerisation by microwave on the physical properties of molecularly imprinted polymers (MIPs) specific for caffeine. Polymer Chemistry. 11(36): 5778-5789.en_US
dc.identifier.urihttp://hdl.handle.net/10454/18143
dc.descriptionYesen_US
dc.description.abstractMolecularly Imprinted Polymers (MIPs) are a class of polymeric materials that exhibit highly specific recognition properties towards a chosen target. These “smart materials” offer robustness to work in extreme environmental conditions and cost effectiveness; and have shown themselves capable of the affinities/specificities observed of their biomolecular counterparts. Despite this, in many MIP systems heterogeneity generated in the polymerisation process is known to affect the performance. Microwave reactors have been extensively studied in organic chemistry because they can afford fast and well-controlled reactions, and have been used for polymerisation reactions; however, their use for creating MIPs is limited. Here we report a case study of a model MIP system imprinted for caffeine, using microwave initiation. Experimental parameters such as polymerisation time, temperature and applied microwave power have been investigated and compared with polymers prepared by oven and UV irradiation. MIPs have been characterised by BET, SEM, DSC, TGA, NMR, and HPLC for their physical properties and analyte recognition performance. The results suggest that the performance of these polymers correlates to their physical characteristics. These characteristics were significantly influenced by changes in the experimental polymerisation parameters, and the complexity of the component mixture. A series of trends were observed as each parameter was altered, suggesting that the performance of a generated polymer could be possible to predict. As expected, component selection is shown to be a major factor in the success of an imprint using this method, but this also has a significant effect on the quality of resultant polymers suggesting that only certain types of MIPs can be made using microwave irradiation. This work also indicates that the controlled polymerisation conditions offered by microwave reactors could open a promising future in the development of MIPs with more predictable analyte recognition performance, assuming material selection lends itself to this type of initiation.en_US
dc.description.sponsorshipDMU School of Pharmacy undergraduate project scheme for financial support.en_US
dc.language.isoenen_US
dc.publisherRoyal Society of Chemistry
dc.relation.isreferencedbyhttps://doi.org/10.1039/D0PY00921Ken_US
dc.rights© 2020 Royal Society of Chemistry. Reproduced in accordance with the publisher's self-archiving policy.en_US
dc.subjectMolecularly Imprinted Polymers (MIPs)en_US
dc.subject“Smart materials”en_US
dc.subjectPolymerisation processen_US
dc.subjectMicrowave reactorsen_US
dc.subjectCaffeineen_US
dc.titleEffect of polymerisation by microwave on the physical properties of molecularly imprinted polymers (MIPs) specific for caffeineen_US
dc.status.refereedYesen_US
dc.date.Accepted2020-08-12
dc.date.application2020-08-12
dc.typeArticleen_US
dc.type.versionAccepted manuscripten_US
dc.date.updated2020-10-14T07:48:25Z
refterms.dateFOA2020-10-28T09:36:39Z


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