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    Synthesis, characterisation, and in vitro anticancer activity of catalytically active indole-based half-sandwich complexes

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    soldevila-barreda_et_al_2020.pdf (2.417Mb)
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    Publication date
    2020-10-03
    Author
    Soldevila-Barreda, Joan J.
    Fawibe, K.B.
    Azmanova, Maria
    Rafols, Laia
    Pitto-Barry, Anaïs
    Eke, U.B.
    Barry, Nicolas P.E.
    Keyword
    Indole
    Half-sandwich complexes
    Bioinorganic chemistry
    Catalytic drugs
    Anticancer
    Rights
    (c) 2020 The Authors. This is an Open Access article distributed under the Creative Commons CC-BY license (https://creativecommons.org/licenses/by/4.0/)
    Peer-Reviewed
    Yes
    
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    Abstract
    The synthesis, characterisation and evaluation of the in vitro cytotoxicity of four indole-based half-sandwich metal complexes towards two ovarian cancer cell lines (A2780 and A2780cisR) and one normal prostate cell line (PNT2) are presented herein. Although capable of inducing catalytic oxidation of NADH and able to reduce NAD+ with high turnover frequencies, in cells and in the presence of sodium formate, these complexes also strongly interact with biomolecules such as glutathione. This work highlights that efficient out-of-cells catalytic activity might lead to higher reactivity towards biomolecules, thus inhibiting the in-cells catalytic processes.
    URI
    http://hdl.handle.net/10454/18070
    Version
    Published version
    Citation
    Soldevila-Barreda JJ, Fawibe KB, Azmanova M et al (2020) Synthesis, characterisation, and in vitro anticancer activity of catalytically active indole-based half-sandwich complexes. Molecules. 25(19): 4540.
    Link to publisher’s version
    https://doi.org/10.3390/molecules25194540
    Type
    Article
    Collections
    Life Sciences Publications

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