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dc.contributor.authorAlsirawan, M.H.D. Bashir
dc.contributor.authorLai, X.
dc.contributor.authorProhens, R.
dc.contributor.authorVangala, Venu R.
dc.contributor.authorShelley, P.
dc.contributor.authorBannan, T.J.
dc.contributor.authorTopping, D.O.
dc.contributor.authorParadkar, Anant R
dc.date.accessioned2020-08-22T08:27:14Z
dc.date.accessioned2020-09-30T14:14:43Z
dc.date.available2020-08-22T08:27:14Z
dc.date.available2020-09-30T14:14:43Z
dc.date.issued2020-07
dc.identifier.citationAlsirawan MHDB, Lai X, Prohens R et al (2020) Mechanistic understanding of competitive destabilization of carbamazepine cocrystals under solvent free conditions. Crystal Growth and Design. 20(9): 6024-6029.en_US
dc.identifier.urihttp://hdl.handle.net/10454/18061
dc.descriptionNoen_US
dc.description.abstractMechanistic understanding of competitive destabilization of carbamazepine:nicotinamide and carbamazepine:saccharin cocrystals under solvent free conditions has been investigated. The crystal phase transformations were monitored using hot stage microscopy, variable-temperature powder X-ray diffraction, and sublimation experiments. The destabilization of the two cocrystals occurs via two distinct mechanisms: vapor and eutectic phase formations. Vapor pressure measurements and thermodynamic calculations using fusion and sublimation enthalpies were in good agreement with experimental findings. The mechanistic understanding is important to maintain the stability of cocrystals during solvent free green manufacturing.en_US
dc.description.sponsorshipEPSRC (EP/J003360/1, EP/ L027011/1). MHD. Bashir would like to thank CARA for providing doctoral degree scholarship.en_US
dc.language.isoenen_US
dc.subjectCocrystalen_US
dc.subjectDestabilisationen_US
dc.subjectVapour pressureen_US
dc.subjectCarbamazepineen_US
dc.titleMechanistic understanding of competitive destabilization of carbamazepine cocrystals under solvent free conditionsen_US
dc.status.refereedYesen_US
dc.date.Accepted2020-07
dc.date.application2020-07-31
dc.typeArticleen_US
dc.type.versionNo full-text in the repositoryen_US
dc.identifier.doihttps://doi.org/10.1021/acs.cgd.0c00735
dc.date.updated2020-08-22T07:27:22Z
refterms.dateFOA2020-09-30T14:15:38Z


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