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dc.contributor.authorMaher, S.G.
dc.contributor.authorBibby, B.A.S.
dc.contributor.authorMoody, Hannah L.
dc.contributor.authorReid, G.
dc.date.accessioned2020-09-27T09:29:16Z
dc.date.available2020-09-27T09:29:16Z
dc.date.issued2015
dc.identifier.citationMaher SG, Bibby BAS, Moody HL et al (2015) Chapter 4 - MicroRNAs and Cancer. In: Gray SG (Ed)Epigenetic Cancer Therapy. London: Academic Press: 67-90.en_US
dc.identifier.urihttp://hdl.handle.net/10454/18035
dc.descriptionNoen_US
dc.description.abstractMicroRNAs are a relatively new class of small, noncoding RNA species that represent a cornerstone of cell biology, with diverse roles ranging from embryonic development to aging. miRNAs function to regulate posttranscriptional gene expression, are critical to the normal function of cells, and as such are frequently dysregulated during disease processes. In this chapter, we discuss the biogenesis and mechanism of action of miRNA and their role in cancer initiation, promotion, and progression. In addition, we discuss the most recently identified dual roles of miRNA in epigenetic gene regulation; how they are both regulators and regulated. Finally, we discuss the emerging roles of miRNA as epigenetic anti-cancer therapeutics, the current research examining inhibition of oncogenic miRNAs, and studies now establishing the potential of replacing lost, tumor-suppressive miRNA.en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttps://doi.org/10.1016/B978-0-12-800206-3.00004-5en_US
dc.subjectMicroRNAen_US
dc.subjectTranslational repressionen_US
dc.subjectoncomiRen_US
dc.subjectCanceren_US
dc.subjectepi-miRNAen_US
dc.subjectantimiRen_US
dc.subjectMiRNA mimicen_US
dc.subjectmiRNA replacement therapyen_US
dc.titleMicroRNAs and Canceren_US
dc.status.refereedYesen_US
dc.typeBook chapteren_US
dc.type.versionNo full-text in the repositoryen_US


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