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    MicroRNAs and Cancer

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    Publication date
    2015
    Author
    Maher, S.G.
    Bibby, B.A.S.
    Moody, Hannah L.
    Reid, G.
    Keyword
    MicroRNA
    Translational repression
    oncomiR
    Cancer
    epi-miRNA
    antimiR
    MiRNA mimic
    miRNA replacement therapy
    Peer-Reviewed
    Yes
    
    Metadata
    Show full item record
    Abstract
    MicroRNAs are a relatively new class of small, noncoding RNA species that represent a cornerstone of cell biology, with diverse roles ranging from embryonic development to aging. miRNAs function to regulate posttranscriptional gene expression, are critical to the normal function of cells, and as such are frequently dysregulated during disease processes. In this chapter, we discuss the biogenesis and mechanism of action of miRNA and their role in cancer initiation, promotion, and progression. In addition, we discuss the most recently identified dual roles of miRNA in epigenetic gene regulation; how they are both regulators and regulated. Finally, we discuss the emerging roles of miRNA as epigenetic anti-cancer therapeutics, the current research examining inhibition of oncogenic miRNAs, and studies now establishing the potential of replacing lost, tumor-suppressive miRNA.
    URI
    http://hdl.handle.net/10454/18035
    Version
    No full-text in the repository
    Citation
    Maher SG, Bibby BAS, Moody HL et al (2015) Chapter 4 - MicroRNAs and Cancer. In: Gray SG (Ed)Epigenetic Cancer Therapy. London: Academic Press: 67-90.
    Link to publisher’s version
    https://doi.org/10.1016/B978-0-12-800206-3.00004-5
    Type
    Book chapter
    Collections
    Life Sciences Publications

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