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    Ex vivo and in vitro evaluation of the influence of the inhaler device and formulation on lung deposition of budesonide

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    Publication date
    2020-07-15
    Author
    Aloum, Fatima
    Al Ayoub, Yuosef
    Mohammad, Mohammad A.
    Obeed, Muthana
    Paluch, Krzysztof J.
    Assi, Khaled H.
    Keyword
    Budesonide DPI formulation Dry powder inhaler Ex vivo. Surface energy In-Check DIAL Lung deposition
    Budesonide
    DPI formulation
    Lung deposition
    Dry powder inhaler
    Ex vivo
    Surface energy
    In-check DIAL
    Rights
    © 2020 Elsevier. Reproduced in accordance with the publisher's self-archiving policy. This manuscript version is made available under the CC-BY-NC-ND 4.0 license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
    Peer-Reviewed
    Yes
    
    Metadata
    Show full item record
    Abstract
    Two different types of dry powder inhalers (Easyhaler® and RS01®) were used in this work to evaluate the ex vivo and in vitro performance of a budesonide inhaled formulation with recrystallised mannitol, commercial DPI-grade mannitol, or lactose. The aerodynamic performance of the budesonide formulation with recrystallised mannitol was superior when RS01® was used (FPF = 45.8%) compared to Easyhaler® (FPF = 14%). However, the aerodynamic profile was very poor in both devices when commercial mannitol was used. Interestingly, the aerosol performance of the marketed budesonide formulation significantly improved when RS01® was used compared to Easyhaler® (the original device for the formulation). Due to the significant increases in the surface energy of the commercial mannitol formulation, the aerodynamic performance of the formulation was very poor. This work demonstrates the impact of inhaler devices on the performance of inhaled formulations and considers the particle surface energy during formulation development.
    URI
    http://hdl.handle.net/10454/17991
    Version
    Accepted manuscript
    Citation
    Aloum F, Al Ayoub Y, Mohammad MA et al (2020) Ex vivo and in vitro evaluation of the influence of the inhaler device and formulation on lung deposition of budesonide. Powder Technology. 372: 685-693.
    Link to publisher’s version
    https://doi.org/10.1016/j.powtec.2020.06.037
    Type
    Article
    Collections
    Life Sciences Publications

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