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dc.contributor.authorKitching, V.R.
dc.contributor.authorRahmanian, Nejat
dc.contributor.authorJamaluddin, N.H.
dc.contributor.authorKelly, Adrian L.
dc.date.accessioned2020-06-17T09:54:15Z
dc.date.accessioned2020-07-07T12:35:39Z
dc.date.available2020-06-17T09:54:15Z
dc.date.available2020-07-07T12:35:39Z
dc.date.issued2020-08
dc.identifier.citationKitching VR, Rahmanian N, Jamaluddin NH et al (2020) Influence of type of granulators on formation of seeded granules. Chemical Engineering Research and Design. 160: 154-161.en_US
dc.identifier.urihttp://hdl.handle.net/10454/17907
dc.descriptionYesen_US
dc.description.abstractIt has been shown that seeded granules of calcium carbonate can be produced in commercial batch high shear granulators such as the Cyclomix high-shear impact mixer. Seeded granules are attractive to the pharmaceutical industry due to their high uniformity and good mechanical properties which can assist efficient tablet manufacture. In the current study, attempts to produce seeded granules of Durcal 65 and PEG 4000 binder using hot melt granulation are reported, in response to the recent shift towards continuous pharmaceutical manufacturing. Various screw configurations and rotation speeds were investigated in a series of experiments to determine the relationship between process conditions and granule properties. Particle size analysis, strength measurement and structural characterisation were used to quantify granule properties. It was found that using a series of kneading elements arranged at a 60° staggering angle located near to the feed section of the extruder screw generated strong, spherical granules. From structural characterisation approximately 5–15% of extruded granules were found to be seeded. Twin screw melt granulation is therefore considered to be a promising technique for continuous production of seeded granules, although a more detailed investigation is required to optimise yield and quality.en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttps://doi.org/10.1016/j.cherd.2020.05.017en_US
dc.rights(c) 2020 Institution of Chemical Engineers. Published by Elsevier. Reproduced in accordance with the publisher's self-archiving policy. This manuscript version is made available under the CC-BY-NC-ND 4.0 license.
dc.subjectSeeded granulationen_US
dc.subjectTwin-screw extruderen_US
dc.subjectMelt granulationen_US
dc.subjectStrength analysisen_US
dc.titleInfluence of type of granulators on formation of seeded granulesen_US
dc.status.refereedYesen_US
dc.date.Accepted2020-05-16
dc.contributor.sponsorCCIP grant (Collaboration, Capacity and IP Develop-ment) fund from the University of Bradford.
dc.date.application2020-05-26
dc.typeArticleen_US
dc.date.EndofEmbargo2022-05-27
dc.type.versionAccepted manuscripten_US
dc.description.publicnotesThe full-text of this article will be released for public view at the end of the publisher embargo on 27 May 2022.
dc.date.updated2020-06-17T08:54:17Z


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