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dc.contributor.authorHelfer, Gisela
dc.contributor.authorStevenson, T.J.
dc.date.accessioned2020-06-24T09:58:54Z
dc.date.available2020-06-24T09:58:54Z
dc.date.issued2020
dc.identifier.citationHelfer G and Stevenson TJ (2020) Pleiotropic effects of proopiomelanocortin and VGF nerve growth factor inducible neuropeptides for the long-term regulation of energy balance. Molecular Cell Endocrinology. 514: 110876en_US
dc.identifier.urihttp://hdl.handle.net/10454/17864
dc.descriptionyesen_US
dc.description.abstractSeasonal rhythms in energy balance are well documented across temperate and equatorial zones animals. The long-term regulated changes in seasonal physiology consists of a rheostatic system that is essential to successful time annual cycles in reproduction, hibernation, torpor, and migration. Most animals use the annual change in photoperiod as a reliable and robust environmental cue to entrain endogenous (i.e. circannual) rhythms. Research over the past few decades has predominantly examined the role of first order neuroendocrine peptides for the rheostatic changes in energy balance. These anorexigenic and orexigenic neuropeptides in the arcuate nucleus include neuropeptide y (Npy), agouti-related peptide (Agrp), cocaine and amphetamine related transcript (Cart) and pro-opiomelanocortin (Pomc). Recent studies also indicate that VGF nerve growth factor inducible (Vgf) in the arcuate nucleus is involved in the seasonal regulation of energy balance. In situ hybridization, qPCR and RNA-sequencing studies have identified that Pomc expression across fish, avian and mammalian species, is a neuroendocrine marker that reflects seasonal energetic states. Here we highlight that long-term changes in arcuate Pomc and Vgf expression is conserved across species and may provide rheostatic regulation of seasonal energy balance.en_US
dc.description.sponsorshipAcademy of Medical Sciences, Leverhulme Trusten_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttps://doi.org/10.1016/j.mce.2020.110876en_US
dc.rights© 2020 Elsevier. Reproduced in accordance with the publisher's self-archiving policy. This manuscript version is made available under the CC-BY-NC-ND 4.0 license.en_US
dc.subjectPro-opiomelanocortin (Pomc)en_US
dc.subjectRetinoic aciden_US
dc.subjectSeasonalen_US
dc.subjectTanycytesen_US
dc.subjectThyroiden_US
dc.subjectVGF nerve growth factor inducible (VGF)en_US
dc.subjectSeasonal rhythmsen_US
dc.subjectEnergy balanceen_US
dc.titlePleiotropic Effects of Proopiomelanocortin and VGF Nerve Growth Factor Inducible Neuropeptides for the Long-Term Regulation of Energy Balanceen_US
dc.status.refereedYesen_US
dc.date.Accepted2020-05-18
dc.date.application2020-05-27
dc.typeArticleen_US
dc.type.versionAccepted manuscripten_US
refterms.dateFOA2020-06-24T10:03:40Z


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