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    Pleiotropic Effects of Proopiomelanocortin and VGF Nerve Growth Factor Inducible Neuropeptides for the Long-Term Regulation of Energy Balance

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    Publication date
    2020
    Author
    Helfer, Gisela
    Stevenson, T.J.
    Keyword
    Pro-opiomelanocortin (Pomc)
    Retinoic acid
    Seasonal
    Tanycytes
    Thyroid
    VGF nerve growth factor inducible (VGF)
    Seasonal rhythms
    Energy balance
    Rights
    © 2020 Elsevier. Reproduced in accordance with the publisher's self-archiving policy. This manuscript version is made available under the CC-BY-NC-ND 4.0 license.
    Peer-Reviewed
    Yes
    
    Metadata
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    Abstract
    Seasonal rhythms in energy balance are well documented across temperate and equatorial zones animals. The long-term regulated changes in seasonal physiology consists of a rheostatic system that is essential to successful time annual cycles in reproduction, hibernation, torpor, and migration. Most animals use the annual change in photoperiod as a reliable and robust environmental cue to entrain endogenous (i.e. circannual) rhythms. Research over the past few decades has predominantly examined the role of first order neuroendocrine peptides for the rheostatic changes in energy balance. These anorexigenic and orexigenic neuropeptides in the arcuate nucleus include neuropeptide y (Npy), agouti-related peptide (Agrp), cocaine and amphetamine related transcript (Cart) and pro-opiomelanocortin (Pomc). Recent studies also indicate that VGF nerve growth factor inducible (Vgf) in the arcuate nucleus is involved in the seasonal regulation of energy balance. In situ hybridization, qPCR and RNA-sequencing studies have identified that Pomc expression across fish, avian and mammalian species, is a neuroendocrine marker that reflects seasonal energetic states. Here we highlight that long-term changes in arcuate Pomc and Vgf expression is conserved across species and may provide rheostatic regulation of seasonal energy balance.
    URI
    http://hdl.handle.net/10454/17864
    Version
    Accepted manuscript
    Citation
    Helfer G and Stevenson TJ (2020) Pleiotropic effects of proopiomelanocortin and VGF nerve growth factor inducible neuropeptides for the long-term regulation of energy balance. Molecular Cell Endocrinology. 514: 110876
    Link to publisher’s version
    https://doi.org/10.1016/j.mce.2020.110876
    Type
    Article
    Collections
    Life Sciences Publications

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