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dc.contributor.authorEgleston, B.D.
dc.contributor.authorBrand, M.C.
dc.contributor.authorGreenwell, F.
dc.contributor.authorBriggs, M.E.
dc.contributor.authorJames, S.L.
dc.contributor.authorCooper, A.I.
dc.contributor.authorCrawford, Deborah E.
dc.contributor.authorGreenaway, R.L.
dc.date.accessioned2020-05-25T12:21:57Z
dc.date.accessioned2020-06-11T13:33:08Z
dc.date.available2020-05-25T12:21:57Z
dc.date.available2020-06-11T13:33:08Z
dc.date.issued2020-07
dc.identifier.citationEgleston BD, Brand MC, Greenwell F et al (2020) Continuous and scalable synthesis of a porous organic cage by twin screw extrusion (TSE). Chemical Science. 11(25): 6582-6589.en_US
dc.identifier.urihttp://hdl.handle.net/10454/17844
dc.descriptionYesen_US
dc.description.abstractThe continuous and scalable synthesis of a porous organic cage (CC3), obtained through a 10-component imine polycondensation between triformylbenzene and a vicinal diamine, was achieved using twin screw extrusion (TSE). Compared to both batch and flow syntheses, the use of TSE enabled the large scale synthesis of CC3 using minimal solvent and in short reaction times, with liquid-assisted grinding (LAG) also promoting window-to-window crystal packing to form a 3-D diamondoid pore network in the solid state. A new kinetically trapped [3+5] product was also observed alongside the formation of the targeted [4+6] cage species. Post-synthetic purification by Soxhlet extraction of the as-extruded ‘technical grade’ mixture of CC3 and [3+5] species rendered the material porous.en_US
dc.description.sponsorshipEngineering and Physical Sciences Research Council (EPSRC) under the Grants EP/R005710/1 (AIC) and EP/R005540/1 (SLJ), and for an EPSRC Summer Vacation Bursary at the University of Liverpool (FG, RLG). We also thank the European Research Council under FP7, RobOT, ERC Grant Agreement No. 321156 (AIC), for financial support. RLG thanks the Royal Society for a University Research Fellowship.en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttps://doi.org/10.1039/D0SC01858Aen_US
dc.rights© The Royal Society of Chemistry 2020. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence (https://creativecommons.org/licenses/by-nc/3.0/).en_US
dc.subjectTwin screw extrusion (TSE)en_US
dc.subjectContinuous synthesisen_US
dc.subjectScalable synthesisen_US
dc.subjectPorous organic cage (CC3)en_US
dc.titleContinuous and scalable synthesis of a porous organic cage by twin screw extrusion (TSE)en_US
dc.status.refereedYesen_US
dc.date.Accepted2020-05-10
dc.date.application2020-05-11
dc.typeArticleen_US
dc.type.versionPublished versionen_US
dc.date.updated2020-05-25T11:21:58Z
refterms.dateFOA2020-06-11T13:34:59Z


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