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dc.contributor.authorGroschel, M.I.
dc.contributor.authorMeehan, Conor J.
dc.contributor.authorBarilar, I.
dc.contributor.authorDiricks, M.
dc.contributor.authorGonzaga, A.
dc.contributor.authorSteglich, M.
dc.contributor.authorConchillo-Solé, O.
dc.contributor.authorScherer, I.-C.
dc.contributor.authorMamat, U.
dc.contributor.authorLuz, C.F.
dc.contributor.authorDe Bruyne, K.
dc.contributor.authorUtpatel, C.
dc.contributor.authorYero, D.
dc.contributor.authorGilbert, I.
dc.contributor.authorDaura, X.
dc.contributor.authorKampmeier, S.
dc.contributor.authorRahman1, N.A.
dc.contributor.authorKresken, M.
dc.contributor.authorvan der Werf, T.S.
dc.contributor.authorAlio, I.
dc.contributor.authorStreit, W.R.
dc.contributor.authorZhou, K.
dc.contributor.authorSchwartz, Z.
dc.contributor.authorRossen, J.W.A.
dc.contributor.authorFarhat, M.R.
dc.contributor.authorSchaible, U.E.
dc.contributor.authorNübel, U.
dc.contributor.authorRupp, J.
dc.contributor.authorSteinmann, J.
dc.contributor.authorNiemann, S.
dc.contributor.authorKohl, T.A.
dc.date.accessioned2020-05-05T14:59:59Z
dc.date.accessioned2020-05-13T12:49:51Z
dc.date.available2020-05-05T14:59:59Z
dc.date.available2020-05-13T12:49:51Z
dc.date.issued2020-04
dc.identifier.citationGroschel MI, Meehan CJ, Barilar I, et al (2020) The phylogenetic landscape and nosocomial spread of the multidrug-resistant opportunist Stenotrophomonas maltophilia. Nature Communications, 11 (Article 2044): 1-12.en_US
dc.identifier.urihttp://hdl.handle.net/10454/17801
dc.descriptionyesen_US
dc.description.abstractRecent studies portend a rising global spread and adaptation of human- or healthcare- associated pathogens. Here, we analyse an international collection of the emerging, multi-drug-resistant, opportunistic pathogen Stenotrophomonas maltophilia from 22 countries to infer population structure and clonality at a global level. We show that the S. maltophilia complex is divided into 23 monophyletic lineages, most of which harbour strains of all degrees of human virulence. Lineage Sm6 comprises the highest rate of human-associated strains, linked to key virulence and resistance genes. Transmission analysis identifies potential outbreak events of genetically closely related strains isolated within days or weeks in the same hospitals.en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttps://doi.org/10.1038/s41467-020-15123-0en_US
dc.rights© 2020 The Authors. Published by Nature Publishing. This work is licensed under a Creative Commons Attribution 4.0 International License. http://creativecommons.org/licenses/by/4.0/en_US
dc.subjectStenotrophomonas maltophiliaen_US
dc.subjectMonophyletic lineagesen_US
dc.subjectVirulenceen_US
dc.subjectTransmission analysisen_US
dc.subjectNosocomial spreaden_US
dc.subjectMultidrug-resistanceen_US
dc.titleThe phylogenetic landscape and nosocomial spread of the multidrug-resistant opportunist Stenotrophomonas maltophiliaen_US
dc.status.refereedyesen_US
dc.date.Accepted2020-02-15
dc.date.application2020-04-27
dc.typeArticleen_US
dc.type.versionPublished versionen_US
dc.date.updated2020-05-05T14:00:00Z
refterms.dateFOA2020-05-13T12:53:32Z


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