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    Endocrine drivers of photoperiod response

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    Publication date
    2020-04
    Author
    Helfer, Gisela
    Dumbell, R.
    Keyword
    Photoperiod
    Seasonal
    Hypothalamus
    Bodyweight
    Appetite
    Growth
    Rights
    © 2020 Elsevier. Reproduced in accordance with the publisher's self-archiving policy. This manuscript version is made available under the CC-BY-NC-ND 4.0 license.
    Peer-Reviewed
    Yes
    
    Metadata
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    Abstract
    Life in a seasonally variable environment has evolved to interpret the time of year through day length (photoperiod) which is translated into a neurochemical signal. In mammals, the pars tuberalis is a key site where seasonal time signal (melatonin) interfaces and relays photoperiodic information to the hypothalamus via thyrotropin. Recent work has elucidated a potential circannual clock in ‘calendar cells’ of the pars tuberalis. In the hypothalamus, tanycytes are an integral part of the hypothalamic network. Previous studies show the importance of local synthesis of thyroid hormone and retinoic acid in tanycytes. Recently novel downstream neuroendocrine signals, e.g. VGF, FGF21 and chemerin, were identified to govern seasonally appropriate phenotype. Additionally, the hypothalamic-pituitary-growth axis has been implicated in seasonally bodyweight and torpor regulation. Here, we will focus on the endocrine drivers of photoperiod response and highlight novel downstream effects on bodyweight and growth focusing on recent findings from seasonal rodent studies.
    URI
    http://hdl.handle.net/10454/17787
    Version
    Accepted manuscript
    Citation
    Helfer G and Dumbell R (2020) Endocrine drivers of photoperiod response. Current Opinion in Endocrine and Metabolic Research. 11: 49-54.
    Link to publisher’s version
    https://doi.org/10.1016/j.coemr.2020.01.001
    Type
    Article
    Collections
    Life Sciences Publications

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