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2020-04Rights
© 2020 Elsevier. Reproduced in accordance with the publisher's self-archiving policy. This manuscript version is made available under the CC-BY-NC-ND 4.0 license.Peer-Reviewed
YesOpen Access status
openAccessAccepted for publication
2020-01-06
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Life in a seasonally variable environment has evolved to interpret the time of year through day length (photoperiod) which is translated into a neurochemical signal. In mammals, the pars tuberalis is a key site where seasonal time signal (melatonin) interfaces and relays photoperiodic information to the hypothalamus via thyrotropin. Recent work has elucidated a potential circannual clock in ‘calendar cells’ of the pars tuberalis. In the hypothalamus, tanycytes are an integral part of the hypothalamic network. Previous studies show the importance of local synthesis of thyroid hormone and retinoic acid in tanycytes. Recently novel downstream neuroendocrine signals, e.g. VGF, FGF21 and chemerin, were identified to govern seasonally appropriate phenotype. Additionally, the hypothalamic-pituitary-growth axis has been implicated in seasonally bodyweight and torpor regulation. Here, we will focus on the endocrine drivers of photoperiod response and highlight novel downstream effects on bodyweight and growth focusing on recent findings from seasonal rodent studies.Version
Accepted manuscriptCitation
Helfer G and Dumbell R (2020) Endocrine drivers of photoperiod response. Current Opinion in Endocrine and Metabolic Research. 11: 49-54.Link to Version of Record
https://doi.org/10.1016/j.coemr.2020.01.001Type
Articleae974a485f413a2113503eed53cd6c53
https://doi.org/10.1016/j.coemr.2020.01.001