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    A statistical analysis of murine incisional and excisional acute wound models

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    ansell_et_al_2014.pdf (652.4Kb)
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    Publication date
    2014-03
    Author
    Ansell, David M.
    Campbell, L.
    Thomason, H.A.
    Brass, A.
    Hardman, M.J.
    Keyword
    Murine wound model
    Wound healing
    Rights
    (c) 2014 The Authors. This is an Open Access article distributed under the Creative Commons CC-BY license (http://creativecommons.org/licenses/by/4.0/)
    Peer-Reviewed
    Yes
    
    Metadata
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    Abstract
    Mice represent the most commonly used species for preclinical in vivo research. While incisional and excisional acute murine wound models are both frequently employed, there is little agreement on which model is optimum. Moreover, current lack of standardization of wounding procedure, analysis time point(s), method of assessment, and the use of individual wounds vs. individual animals as replicates makes it difficult to compare across studies. Here we have profiled secondary intention healing of incisional and excisional wounds within the same animal, assessing multiple parameters to determine the optimal methodology for future studies. We report that histology provides the least variable assessment of healing. Furthermore, histology alone (not planimetry) is able to detect accelerated healing in a castrated mouse model. Perhaps most importantly, we find virtually no correlation between wounds within the same animal, suggesting that use of wound (not animal) biological replicates is perfectly acceptable. Overall, these findings should guide and refine future studies, increasing the likelihood of detecting novel phenotypes while reducing the numbers of animals required for experimentation.
    URI
    http://hdl.handle.net/10454/17777
    Version
    Published version
    Citation
    Ansell DM, Campbell L, Thomason HA et al (2014) A statistical analysis of murine incisional and excisional acute wound models. Wound Repair and Regeneration. 22(2): 281-287.
    Link to publisher’s version
    https://doi.org/10.1111/wrr.12148
    Type
    Article
    Collections
    Life Sciences Publications

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