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dc.contributor.authorCrawford, Deborah E.
dc.contributor.authorMiskimmin, C.K.
dc.contributor.authorCahir, J.
dc.contributor.authorJames, S.L.
dc.date.accessioned2020-02-13T12:35:08Z
dc.date.accessioned2020-03-09T12:34:16Z
dc.date.available2020-02-13T12:35:08Z
dc.date.available2020-03-09T12:34:16Z
dc.date.issued2017-11
dc.identifier.citationCrawford DE, Miskimmin CK, Cahir J et al (2017) Continuous multi-step synthesis by extrusion - telescoping solvent-free reactions for greater efficiency. Chemical Communications. 53(97): 13067-13070.en_US
dc.identifier.urihttp://hdl.handle.net/10454/17693
dc.descriptionYesen_US
dc.description.abstractChemical manufacturing typically requires more than one step, involving multiple batch processes, which makes synthesis at scale laborious and wasteful. Herein, we demonstrate that several reactions can be telescoped into a single continuous process and/or be carried out as a continuous multi-component reaction (MCR), by twin screw extrusion (TSE), in the complete absence of solvent.en_US
dc.description.sponsorshipEPSRC (EP/L019655/1).en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttps://doi.org/10.1039/C7CC06010Fen_US
dc.rights© The Royal Society of Chemistry 2017. This work is made available online in accordance with the publisher’s policies. Please refer to any applicable terms of use of the publisher.en_US
dc.subjectChemical manufacturingen_US
dc.subjectContinuous multi-step synthesisen_US
dc.subjectMulti-component reaction (MCR)en_US
dc.subjectTwin screw extrusion (TSE)en_US
dc.subjectSolventen_US
dc.titleContinuous multi-step synthesis by extrusion - telescoping solvent-free reactions for greater efficiencyen_US
dc.status.refereedYesen_US
dc.date.Accepted2017-11-10
dc.date.application2017-11-10
dc.typeArticleen_US
dc.type.versionAccepted manuscripten_US
dc.date.updated2020-02-13T12:35:09Z
refterms.dateFOA2020-03-09T12:34:40Z


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