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dc.contributor.authorCao, Q.
dc.contributor.authorHoward, J.L.
dc.contributor.authorCrawford, Deborah E.
dc.contributor.authorJames, S.L.
dc.contributor.authorBrowne, D.L.
dc.date.accessioned2020-02-13T12:24:24Z
dc.date.accessioned2020-03-09T11:22:02Z
dc.date.available2020-02-13T12:24:24Z
dc.date.available2020-03-09T11:22:02Z
dc.date.issued2018-09
dc.identifier.citationCao Q, Howard JL, Crawford DE et al (2018) Translating solid state organic synthesis from a mixer mill to a continuous twin screw extruder. Green Chemistry. 20(19): 4443-4447.en_US
dc.identifier.urihttp://hdl.handle.net/10454/17690
dc.descriptionYesen_US
dc.description.abstractA study on the translation of a solid-state synthetic reaction from a mechanochemical mixer-mill to a continuous twin-screw extruder is discussed herein. The study highlights some considerations to be made and parameters to be tested in the context of a model fluorination reaction, which is the first organic fluorination to be attempted using extrusion. Upon optimization, which features the first use of grinding auxiliary solids to enable effective synthetic extrusion, the difluorination reaction was successfully translated to the extruder, leading to a 100-fold improvement in Space Time Yield (STY); 29 kg m−3 day−1 in a mixer mill to 3395 kg m−3 day−1 in a twin screw extruder.en_US
dc.description.sponsorshipD. L. B is grateful to the EPSRC for a First Grant (D. L. B. EP/P002951/1), CRD for a studentship award to J. L. H., Queen’s University Belfast for a Visiting Research Fellowship and the School of Chemistry at Cardiff University for generous support. S. L. J. is grateful to EPSRC for support (EP/L019655/1).en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttps://doi.org/10.1039/C8GC02036Aen_US
dc.rights© The Royal Society of Chemistry 2018. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (https://creativecommons.org/licenses/by/3.0/).en_US
dc.subjectSolid-state synthetic reactionsen_US
dc.subjectMechanochemical mixer-millen_US
dc.subjectContinuous twin-screw extruderen_US
dc.subjectOrganic fluorinationen_US
dc.titleTranslating solid state organic synthesis from a mixer mill to a continuous twin screw extruderen_US
dc.status.refereedYesen_US
dc.date.Accepted2018-08-23
dc.date.application2018-09-18
dc.typeArticleen_US
dc.type.versionPublished versionen_US
dc.date.updated2020-02-13T12:24:25Z
refterms.dateFOA2020-03-09T11:22:25Z


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