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    Translating solid state organic synthesis from a mixer mill to a continuous twin screw extruder

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    Publication date
    2018-09
    Author
    Cao, Q.
    Howard, J.L.
    Crawford, Deborah E.
    James, S.L.
    Browne, D.L.
    Keyword
    Solid-state synthetic reactions
    Mechanochemical mixer-mill
    Continuous twin-screw extruder
    Organic fluorination
    Rights
    © The Royal Society of Chemistry 2018. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (https://creativecommons.org/licenses/by/3.0/).
    Peer-Reviewed
    Yes
    
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    Abstract
    A study on the translation of a solid-state synthetic reaction from a mechanochemical mixer-mill to a continuous twin-screw extruder is discussed herein. The study highlights some considerations to be made and parameters to be tested in the context of a model fluorination reaction, which is the first organic fluorination to be attempted using extrusion. Upon optimization, which features the first use of grinding auxiliary solids to enable effective synthetic extrusion, the difluorination reaction was successfully translated to the extruder, leading to a 100-fold improvement in Space Time Yield (STY); 29 kg m−3 day−1 in a mixer mill to 3395 kg m−3 day−1 in a twin screw extruder.
    URI
    http://hdl.handle.net/10454/17690
    Version
    Published version
    Citation
    Cao Q, Howard JL, Crawford DE et al (2018) Translating solid state organic synthesis from a mixer mill to a continuous twin screw extruder. Green Chemistry. 20(19): 4443-4447.
    Link to publisher’s version
    https://doi.org/10.1039/C8GC02036A
    Type
    Article
    Collections
    Life Sciences Publications

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