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    A natural solution to photoprotection and isolation of the potent polyene antibiotic, marinomycin A

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    Publication date
    2019-08-28
    Author
    Bailey, C.S.
    Zarins-Tutt, J.S.
    Agbo, M.
    Gao, H.
    Diego-Taboada, A.
    Gan, M.
    Hamed, Refaat B.
    Abraham, E.R.
    Mckenzie, G.
    Evans, P.A.
    Goss, R.J.M.
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    Keyword
    Photoprotection
    Isolation
    Marinomycin A
    Antibiotic
    Lycopodium clavatum
    Rights
    (c) 2019 The Authors. This is an Open Access article distributed under the Creative Commons CC-BY license (http://creativecommons.org/licenses/by-nc/3.0/)
    Peer-Reviewed
    Yes
    
    Metadata
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    Abstract
    The photoprotection and isolation of marinomycin A using sporopollenin exine capsules (SpECs) derived from the spores of the plant Lycopodium clavatum is described. The marinomycins have a particularly short half-life in natural light, which severely impacts their potential biological utility given that they display potent antibiotic and anticancer activity. The SpEC encapsulation of the marinomycin A dramatically increases the half-life of the polyene macrodiolide to the direct exposure to UV radiation by several orders of magnitude, thereby making this a potentially useful strategy for other light sensitive bioactive agents. In addition, we report that the SpECs can also be used to selectively extract culture broths that contain the marinomycins, which provides a significantly higher recovery than with conventional XAD resins and provides concomitant photoprotection.
    URI
    http://hdl.handle.net/10454/17657
    Version
    Published version
    Citation
    Bailey CS, Zarins-Tutt JS, Agbo M et al (2019) A natural solution to photoprotection and isolation of the potent polyene antibiotic, marinomycin A. Chemical Science. 10(32): 7549-7553.
    Link to publisher’s version
    https://doi.org/10.1039/C9SC01375J
    Type
    Article
    Collections
    Life Sciences Publications

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