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dc.contributor.authorShriky, Banah
dc.contributor.authorKelly, Adrian L.
dc.contributor.authorIsreb, Mohammad
dc.contributor.authorBabenko, Maksims
dc.contributor.authorMahmoudi, N.
dc.contributor.authorRogers, S.
dc.contributor.authorShebanova, O.
dc.contributor.authorSnow, T.
dc.contributor.authorGough, Timothy D.
dc.date.accessioned2020-02-14T15:53:26Z
dc.date.available2020-02-14T15:53:26Z
dc.date.issued2020-04-01
dc.identifier.citationShriky B, Kelly A, Isreb M et al (2020) Pluronic F127 thermosensitive injectable smart hydrogels for controlled drug delivery system development. Journal of Colloid and Interface Science. 565: 119-130.en_US
dc.identifier.urihttp://hdl.handle.net/10454/17634
dc.descriptionYesen_US
dc.description.abstractUnderstanding structure-property relationships is critical for the development of new drug delivery systems. This study investigates the properties of Pluronic smart hydrogel formulations for future use as injectable controlled drug carriers. The smart hydrogels promise to enhance patient compliance, decrease side effects and reduce dose and frequency. Pharmaceutically, these systems are attractive due to their unique sol-gel phase transition in the body, biocompatibility, safety and injectability as solutions before transforming into gel matrices at body temperature. We quantify the structural changes of F127 systems under controlled temperature after flow, as experienced during real bodily injection. Empirical formulae combining the coupled thermal and shear dependency are produced to aid future application of these systems. Induced structural transitions measured in-situ by small angle x-ray and neutron scattering reveal mixed oriented structures that can be exploited to tailor the drug release profile.en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttps://doi.org/10.1016/j.jcis.2019.12.096en_US
dc.rights© 2020 The Authors. Published by Elsevier Inc. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/)en_US
dc.subjectThermosensitiveen_US
dc.subjectGelen_US
dc.subjectThermal propertiesen_US
dc.subjectRheological propertiesen_US
dc.subjectSAXSen_US
dc.subjectSANSen_US
dc.subjectDrug releaseen_US
dc.subjectPluronicen_US
dc.subjectColloidal crystalsen_US
dc.subjectDrug delivery systemsen_US
dc.subjectInjectablesen_US
dc.subjectPoloxameren_US
dc.titlePluronic F127 thermosensitive injectable smart hydrogels for controlled drug delivery system developmenten_US
dc.status.refereedYesen_US
dc.date.Accepted2019-12-21
dc.date.application2019-12-23
dc.typeArticleen_US
dc.type.versionPublished versionen_US
refterms.dateFOA2020-02-14T15:55:07Z


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