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dc.contributor.authorShriky, Banah
dc.contributor.authorKelly, Adrian L.
dc.contributor.authorIsreb, Mohammad
dc.contributor.authorBabenko, Maksims
dc.contributor.authorMahmoudi, N.
dc.contributor.authorRogers, S.
dc.contributor.authorShebanova, O.
dc.contributor.authorSnow, T.
dc.contributor.authorGough, Tim
dc.date.accessioned2020-02-14T15:53:26Z
dc.date.available2020-02-14T15:53:26Z
dc.date.issued01/04/2020
dc.identifier.citationShriky B, Kelly A, Isreb M et al (2020) Pluronic F127 thermosensitive injectable smart hydrogels for controlled drug delivery system development. Journal of Colloid and Interface Science. 565: 119-130.
dc.identifier.urihttp://hdl.handle.net/10454/17634
dc.descriptionYes
dc.description.abstractUnderstanding structure-property relationships is critical for the development of new drug delivery systems. This study investigates the properties of Pluronic smart hydrogel formulations for future use as injectable controlled drug carriers. The smart hydrogels promise to enhance patient compliance, decrease side effects and reduce dose and frequency. Pharmaceutically, these systems are attractive due to their unique sol-gel phase transition in the body, biocompatibility, safety and injectability as solutions before transforming into gel matrices at body temperature. We quantify the structural changes of F127 systems under controlled temperature after flow, as experienced during real bodily injection. Empirical formulae combining the coupled thermal and shear dependency are produced to aid future application of these systems. Induced structural transitions measured in-situ by small angle x-ray and neutron scattering reveal mixed oriented structures that can be exploited to tailor the drug release profile.
dc.language.isoen
dc.rights© 2020 The Authors. Published by Elsevier Inc. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/)
dc.subjectThermosensitive
dc.subjectGel
dc.subjectThermal properties
dc.subjectRheological properties
dc.subjectSAXS
dc.subjectSANS
dc.subjectDrug release
dc.subjectPluronic
dc.subjectColloidal crystals
dc.subjectDrug delivery systems
dc.subjectInjectables
dc.subjectPoloxamer
dc.titlePluronic F127 thermosensitive injectable smart hydrogels for controlled drug delivery system development
dc.status.refereedYes
dc.date.application23/12/2019
dc.typeArticle
dc.type.versionPublished version
dc.identifier.doihttps://doi.org/10.1016/j.jcis.2019.12.096
dc.rights.licenseCC-BY
refterms.dateFOA2020-02-14T15:55:07Z
dc.openaccess.statusopenAccess
dc.date.accepted21/12/2019


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