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    Comparative genomics shows differences in the electron transport and carbon metabolic pathways of Mycobacterium africanum relative to Mycobacterium tuberculosis and suggests an adaptation to low oxygen tension

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    Ofori_L6Metabolism_Tuberculosis_2020.pdf (1.962Mb)
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    Publication date
    2020-01
    Author
    Ofori-Anyinam, B.
    Riley, A.J.
    Jobarteh, T.
    Gitteh, E.
    Sarr, B.
    Faal-Jawara, T.I.
    Rigouts, L.
    Senghore, M.
    Kehinde, A.
    Onyejepu, N.
    Antonio, M.
    de Jong, B.C.
    Gehre, F.
    Meehan, Conor J.
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    Keyword
    Tuberculosis
    Mycobacterium africanum
    Mycobacterium tuberculosis
    Genome
    Electron transport
    Carbon metabolism
    Research Development Fund Publication Prize Award
    Rights
    ©2020 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license.
    Peer-Reviewed
    Yes
    
    Metadata
    Show full item record
    Abstract
    The geographically restricted Mycobacterium africanum lineages (MAF) are primarily found in West Africa, where they account for a significant proportion of tuberculosis. Despite this phenomenon, little is known about the co-evolution of these ancient lineages with West Africans. MAF and M. tuberculosis sensu stricto lineages (MTB) differ in their clinical, in vitro and in vivo characteristics for reasons not fully understood. Therefore, we compared genomes of 289 MAF and 205 MTB clinical isolates from the 6 main human-adapted M. tuberculosis complex lineages, for mutations in their Electron Transport Chain and Central Carbon Metabolic pathway in order to explain these metabolic differences. Furthermore, we determined, in silico, whether each mutation could affect the function of genes encoding enzymes in these pathways. We found more mutations with the potential to affect enzymes in these pathways in MAF lineages compared to MTB lineages. We also found that similar mutations occurred in these pathways between MAF and some MTB lineages. Generally, our findings show further differences between MAF and MTB lineages that may have contributed to the MAF clinical and growth phenotype and indicate potential adaptation of MAF lineages to a distinct ecological niche, which we suggest includes areas characterized by low oxygen tension.
    URI
    http://hdl.handle.net/10454/17611
    Version
    Published version
    Citation
    Ofori-Anyinam B, Riley AJ, Jobarteh T et al (2020) Comparative genomics shows differences in the electron transport and carbon metabolic pathways of Mycobacterium africanum relative to Mycobacterium tuberculosis and suggests an adaptation to low oxygen tension. Tuberculosis. 120: 101899.
    Link to publisher’s version
    https://doi.org/10.1016/j.tube.2020.101899
    Type
    Article
    Notes
    Research Development Fund Publication Prize Award winner, January 2020.
    Collections
    Life Sciences Publications

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