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    Back to the beginning: identifying lesions of diffuse idiopathic skeletal hyperostosis before vertebral ankylosis

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    Castells_Navarro_&_Buckberry_IJP.pdf (432.7Kb)
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    Publication date
    2020-03
    Author
    Castells Navarro, Laura
    Buckberry, Jo
    Keyword
    DISH
    Spinal manifestations
    Extra-spinal manifestations
    Vertebral bone outgrowths
    Vertebral endplate degeneration
    Vertebral ankylosis
    Enthesophytes
    Rights
    © 2020 Elsevier Inc. All rights reserved. Reproduced in accordance with the publisher's self-archiving policy. This manuscript version is made available under the CC-BY-NC-ND 4.0 license.
    Peer-Reviewed
    Yes
    
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    Abstract
    Objective: To better understand the pathogenesis of DISH, identifying early or pre-DISH lesions in the spine and investigating the relationship between spinal and extra-spinal manifestations of DISH. Material: 44 skeletonized individuals with DISH from the WM Bass Donated Skeletal Collection. Methods: For each vertebra, location, extension, point of origin and appearance of vertebral outgrowths were recorded. The size of the enthesophytes at the olecranon process, patella and calcaneal tuberosity was measured with digital callipers. Results: At either end of the DISH-ankylosed segment, isolated vertical outgrowths arising from the central third of the anterior aspect of the vertebral body can usually be observed. These bone outgrowths show a well-organized external cortical layer, an internal structure of trabecular bone and usually are unaccompanied by or show minimal associated endplate degeneration. Analysis of the relationship between spinal and extra-spinal manifestations (ESM) suggests great inter-individual variability. No correlation between any ESM and the stage of spinal DISH was found. Conclusions: Small isolated outgrowths represent the earliest stages of the spinal manifestations of DISH. The use of ESM as an indicator of DISH should be undertaken with great caution until the relationship between these two features is understood. Significance: Improved accuracy of paleopathological diagnostic criteria of DISH. Limitations: Small sample comprised of only individuals with DISH. Future research: micro-CT analysis to investigate the internal structure of the spinal lesions. Analysis of extra-spinal enthesophytes in individuals with and without DISH to understand their pathogenesis and association with the spinal lesions in individuals with DISH.
    URI
    http://hdl.handle.net/10454/17581
    Version
    Accepted manuscript
    Citation
    Castells Navarro L and Buckberry J (2020) Back to the beginning: identifying lesions of diffuse idiopathic skeletal hyperostosis prior to vertebral ankylosis. International Journal of Paleopathology. 28: 59-68.
    Link to publisher’s version
    https://doi.org/10.1016/j.ijpp.2019.12.004
    Type
    Article
    Collections
    Life Sciences Publications

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