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dc.contributor.authorOtchere, I.D.
dc.contributor.authorCoscollá, M.
dc.contributor.authorSánchez-Busó, L.
dc.contributor.authorAsante-Poku, A.
dc.contributor.authorBrites, D.
dc.contributor.authorLoiseau, C.
dc.contributor.authorMeehan, Conor J.
dc.contributor.authorOsei-Wusu, S.
dc.contributor.authorForson, A.
dc.contributor.authorLaryea, C.
dc.contributor.authorYahayah, A.I.
dc.contributor.authorBaddoo, A.
dc.contributor.authorAnsa, G.A.
dc.contributor.authorAboagye, S.Y.
dc.contributor.authorAsare, P.
dc.contributor.authorBorrell, S.
dc.contributor.authorGehre, F.
dc.contributor.authorBeckert, P.
dc.contributor.authorKohl, T.A.
dc.contributor.authorN'dira, S.
dc.contributor.authorBeisel, C.
dc.contributor.authorAntonio, M.
dc.contributor.authorNiemann, S.
dc.contributor.authorde Jong, B.C.
dc.contributor.authorParkhill, J.
dc.contributor.authorHarris, S.R.
dc.contributor.authorGagneux, S.
dc.contributor.authorYeboah-Manu, D.
dc.date.accessioned2020-01-16T10:35:52Z
dc.date.available2020-01-16T10:35:52Z
dc.date.issued2018-07
dc.identifier.citationOtchere ID, Coscollá M, Sánchez-Busó L et al (2018) Comparative genomics of Mycobacterium africanum Lineage 5 and Lineage 6 from Ghana suggests distinct ecological niches. Scientific Reports. 8: 11269.en_US
dc.identifier.urihttp://hdl.handle.net/10454/17572
dc.descriptionYesen_US
dc.description.abstractMycobacterium africanum (Maf) causes a substantial proportion of human tuberculosis in some countries of West Africa, but little is known on this pathogen. We compared the genomes of 253 Maf clinical isolates from Ghana, including N = 175 Lineage 5 (L5) and N = 78 Lineage 6 (L6). We found that the genomic diversity of L6 was higher than in L5 despite the smaller sample size. Regulatory proteins appeared to evolve neutrally in L5 but under purifying selection in L6. Even though over 90% of the human T cell epitopes were conserved in both lineages, L6 showed a higher ratio of non-synonymous to synonymous single nucleotide variation in these epitopes overall compared to L5. Of the 10% human T cell epitopes that were variable, most carried mutations that were lineage-specific. Our findings indicate that Maf L5 and L6 differ in some of their population genomic characteristics, possibly reflecting different selection pressures linked to distinct ecological niches.en_US
dc.description.sponsorshipSupported by the Wellcome Trust Intermediate Fellowship awarded to DYM (Grant Number 097134/Z/11/Z) and by the Swiss National Science Foundation (grants 310030_166687, IZRJZ3_164171 and IZLSZ3_170834), the European Research Council (309540-EVODRTB) and SystemsX.ch.en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttps://doi.org/10.1038/s41598-018-29620-2en_US
dc.rights© The Author(s) 2018. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Te images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.en_US
dc.subjectMycobacterium africanum (Maf)en_US
dc.subjectHuman tuberculosisen_US
dc.subjectGhanaen_US
dc.subjectMolecular ecologyen_US
dc.titleComparative genomics of Mycobacterium africanum Lineage 5 and Lineage 6 from Ghana suggests distinct ecological nichesen_US
dc.status.refereedYesen_US
dc.date.Accepted2018-07-16
dc.date.application2018-07-26
dc.typeArticleen_US
dc.type.versionPublished versionen_US
refterms.dateFOA2020-01-16T10:35:52Z


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