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dc.contributor.authorZhang, X.
dc.contributor.authorMcElwee, Kevin J.
dc.date.accessioned2019-12-10T07:29:36Z
dc.date.accessioned2019-12-16T09:41:17Z
dc.date.available2019-12-10T07:29:36Z
dc.date.available2019-12-16T09:41:17Z
dc.date.issued2020-03
dc.identifier.citationZhang X and McElwee KJ (2020) Allergy promotes alopecia areata in a subset of patients. Experimental Dermatology. 29(3): 239-242.en_US
dc.identifier.urihttp://hdl.handle.net/10454/17535
dc.descriptionYesen_US
dc.description.abstractIn this commentary, we focus on allergy as a facilitating factor in the pathogenesis of alopecia areata (AA). From previous studies on AA, it is well known that subsets of patients can have one or more of; seasonal relapse, comorbid atopic rhinitis, asthma and dermatitis, lesion infiltrating eosinophils and plasma cells, high levels of total IgE, specific IgE for house dust mites (HDMs), and/or disrupted skin barrier function by the evaluation of filaggrin. Allergy and AA share a similar genetic background; both contributing to an immune reaction imbalance. Furthermore, adjunctive treatment with antihistamines, or desensitization for HDM, can reduce the severity of alopecia in atopic AA patients. Therefore, allergies may contribute to the onset and relapse of AA. Identification of an allergic or atopic immune component in AA patient subsets may indicate adjunctive treatment intervention measures against allergies should be taken which may improve the success of conventional AA treatment.en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttps://doi.org/10.1111/exd.14027en_US
dc.rights© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. This is the peer reviewed version of the following article: Zhang X and McElwee KJ (2020) Allergy promotes alopecia areata in a subset of patients. Experimental Dermatology. 29(3): 239-242, which has been published in final form at https://doi.org/10.1111/exd.14027. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.en_US
dc.subjectAllergyen_US
dc.subjectAlopecia areataen_US
dc.subjectAtopyen_US
dc.subjectDust mitesen_US
dc.titleAllergy promotes alopecia areata in a subset of patientsen_US
dc.status.refereedYesen_US
dc.date.Accepted2019-08-15
dc.date.application2019-09-03
dc.typeArticleen_US
dc.type.versionAccepted manuscripten_US
dc.date.updated2019-12-10T07:29:38Z
refterms.dateFOA2019-12-16T09:41:42Z


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