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dc.contributor.authorMuha, V.
dc.contributor.authorWilliamson, Ritchie
dc.contributor.authorHills, R.
dc.contributor.authorMcNeilly, A.D.
dc.contributor.authorMcWilliams, T.G.
dc.contributor.authorAlonso, J.
dc.contributor.authorSchimpl, M.
dc.contributor.authorLeney, A.C.
dc.contributor.authorHeck, A.J.R.
dc.contributor.authorSutherland, C.
dc.contributor.authorRead, K.D.
dc.contributor.authorMcCrimmon, R.J.
dc.contributor.authorBrooks, S.P.
dc.contributor.authorvan Aalten, D.M.F.
dc.date.accessioned2019-11-28T14:30:04Z
dc.date.accessioned2019-12-04T14:08:40Z
dc.date.available2019-11-28T14:30:04Z
dc.date.available2019-12-04T14:08:40Z
dc.date.issued2019-11-06
dc.identifier.citationMuha V, Williamson R, Hills R et al (2019) Loss of CRMP2 O-GlcNAcylation leads to reduced novel object recognition performance in mice. Open Biology. 9(11): 190192.
dc.identifier.urihttp://hdl.handle.net/10454/17525
dc.descriptionYes
dc.description.abstractO-GlcNAcylation is an abundant post-translational modification in the nervous system, linked to both neurodevelopmental and neurodegenerative disease. However, the mechanistic links between these phenotypes and site-specific O-GlcNAcylation remain largely unexplored. Here, we show that Ser517 O-GlcNAcylation of the microtubule-binding protein Collapsin Response Mediator Protein-2 (CRMP2) increases with age. By generating and characterizing a Crmp2S517A knock-in mouse model, we demonstrate that loss of O-GlcNAcylation leads to a small decrease in body weight and mild memory impairment, suggesting that Ser517 O-GlcNAcylation has a small but detectable impact on mouse physiology and cognitive function.
dc.description.sponsorshipa Wellcome Trust Senior Research Fellowship (WT087590MA) to D.M.F.v.A., an ARUK Pilot Project grant to R.W., and support from Tenovus Scotland to V.M. The phosphoproteomics mass spectrometry work was supported by the Horizon 2020 program INFRAIA project Epic-XS (project 823839) to A.J.R.H.
dc.language.isoen
dc.rights© 2019 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.
dc.subjectO-GlcNAcylation
dc.subjectCRMP2
dc.subjectCross talk
dc.subjectCognitive function
dc.titleLoss of CRMP2 O-GlcNAcylation leads to reduced novel object recognition performance in mice
dc.status.refereedYes
dc.date.application2019-11-27
dc.typeArticle
dc.type.versionPublished version
dc.identifier.doihttps://doi.org/10.1098/rsob.190192
dc.rights.licenseCC-BY
dc.date.updated2019-11-28T14:30:05Z
refterms.dateFOA2019-12-04T14:09:15Z
dc.openaccess.statusopenAccess
dc.date.accepted2019-11-05


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