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dc.contributor.authorIsreb, A.
dc.contributor.authorBaj, K.
dc.contributor.authorWojsz, M.
dc.contributor.authorIsreb, Mohammad
dc.contributor.authorPeak, M.
dc.contributor.authorAlhnan, M.A.
dc.date.accessioned2019-11-07T07:59:23Z
dc.date.accessioned2019-11-22T15:05:50Z
dc.date.available2019-11-07T07:59:23Z
dc.date.available2019-11-22T15:05:50Z
dc.date.issued2019-06-10
dc.identifier.citationIsreb A, Baj K, Wojsz K et al (2019) 3D printed oral theophylline doses with innovative 'radiator-like' design: Impact of polyethylene oxide (PEO) molecular weight. International Journal of Pharmaceutics. 564: 98-105.
dc.identifier.urihttp://hdl.handle.net/10454/17496
dc.descriptionYes
dc.description.abstractDespite the abundant use of polyethylene oxides (PEOs) and their integration as an excipient in numerous pharmaceutical products, there have been no previous reports of applying this important thermoplastic polymer species alone to fused deposition modelling (FDM) 3D printing. In this work, we have investigated the manufacture of oral doses via FDM 3D printing by employing PEOs as a backbone polymer in combination with polyethylene glycol (PEG). Blends of PEO (molecular weight 100 K, 200 K, 300 K, 600 K or 900 K) with PEG 6 K (plasticiser) and a model drug (theophylline) were hot-melt extruded. The resultant filaments were used as a feed for FDM 3D printer to fabricate oral dosage forms (ODFs) with innovative designs. ODFs were designed in a radiator-like geometry with connected paralleled plates and inter-plate spacing of either 0.5, 1, 1.5 or 2 mm. X-ray diffraction patterns of the filaments revealed the presence of two distinctive peaks at 2θ = 7° and 12°, which can be correlated to the diffraction pattern of theophylline crystals. Blends of PEO and PEG yielded filaments of variable mechanically resistance (maximum load at break of 357, 608, 649, 882, 781 N for filament produced with PEO 100 K, 200 K, 300 K, 600 K or 900 K, respectively). Filaments of PEO at a molecular weight of 200–600 K were compatible with FDM 3D printing process. Further increase in PEO molecular weight resulted in elevated shear viscosity (>104 Pa.S) at the printing temperature and hindered material flow during FDM 3D printing process. A minimal spacing (1 mm) between parallel plates of the radiator-like design deemed essential to boost drug release from the structure. This is the first report of utilising this widely used biodegradable polymer species (PEOs and PEG) in FDM 3D printing.
dc.language.isoen
dc.rights© 2019 Elsevier B.V. All rights reserved. . Reproduced in accordance with the publisher's self-archiving policy. This manuscript version is made available under the CC-BY-NC-ND 4.0 license.
dc.subjectPersonalised medicine
dc.subjectAdditive manufacturing
dc.subjectComplex structures
dc.subjectTablets
dc.subjectPatient-specific
dc.subjectStructural design
dc.title3D printed oral theophylline doses with innovative 'radiator-like' design: Impact of polyethylene oxide (PEO) molecular weight
dc.status.refereedYes
dc.date.Accepted2019-04-06
dc.date.application2019-04-08
dc.typeArticle
dc.type.versionAccepted manuscript
dc.identifier.doihttps://doi.org/10.1016/j.ijpharm.2019.04.017
dc.rights.licenseCC-BY-NC-ND
dc.date.updated2019-11-07T07:59:25Z
refterms.dateFOA2019-11-22T15:06:17Z
dc.openaccess.statusopenAccess


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