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dc.contributor.authorIsreb, A.
dc.contributor.authorBaj, K.
dc.contributor.authorWojsz, M.
dc.contributor.authorIsreb, Mohammad
dc.contributor.authorPeak, M.
dc.contributor.authorAlhnan, M.A.
dc.date.accessioned2019-11-07T07:59:23Z
dc.date.accessioned2019-11-22T15:05:50Z
dc.date.available2019-11-07T07:59:23Z
dc.date.available2019-11-22T15:05:50Z
dc.date.issued2019-06-10
dc.identifier.citationIsreb A, Baj K, Wojsz K et al (2019) 3D printed oral theophylline doses with innovative 'radiator-like' design: Impact of polyethylene oxide (PEO) molecular weight. International Journal of Pharmaceutics. 564: 98-105.en_US
dc.identifier.urihttp://hdl.handle.net/10454/17496
dc.descriptionYesen_US
dc.description.abstractDespite the abundant use of polyethylene oxides (PEOs) and their integration as an excipient in numerous pharmaceutical products, there have been no previous reports of applying this important thermoplastic polymer species alone to fused deposition modelling (FDM) 3D printing. In this work, we have investigated the manufacture of oral doses via FDM 3D printing by employing PEOs as a backbone polymer in combination with polyethylene glycol (PEG). Blends of PEO (molecular weight 100 K, 200 K, 300 K, 600 K or 900 K) with PEG 6 K (plasticiser) and a model drug (theophylline) were hot-melt extruded. The resultant filaments were used as a feed for FDM 3D printer to fabricate oral dosage forms (ODFs) with innovative designs. ODFs were designed in a radiator-like geometry with connected paralleled plates and inter-plate spacing of either 0.5, 1, 1.5 or 2 mm. X-ray diffraction patterns of the filaments revealed the presence of two distinctive peaks at 2θ = 7° and 12°, which can be correlated to the diffraction pattern of theophylline crystals. Blends of PEO and PEG yielded filaments of variable mechanically resistance (maximum load at break of 357, 608, 649, 882, 781 N for filament produced with PEO 100 K, 200 K, 300 K, 600 K or 900 K, respectively). Filaments of PEO at a molecular weight of 200–600 K were compatible with FDM 3D printing process. Further increase in PEO molecular weight resulted in elevated shear viscosity (>104 Pa.S) at the printing temperature and hindered material flow during FDM 3D printing process. A minimal spacing (1 mm) between parallel plates of the radiator-like design deemed essential to boost drug release from the structure. This is the first report of utilising this widely used biodegradable polymer species (PEOs and PEG) in FDM 3D printing.en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttps://doi.org/10.1016/j.ijpharm.2019.04.017en_US
dc.rights© 2019 Elsevier B.V. All rights reserved. . Reproduced in accordance with the publisher's self-archiving policy. This manuscript version is made available under the CC-BY-NC-ND 4.0 license.en_US
dc.subjectPersonalised medicineen_US
dc.subjectAdditive manufacturingen_US
dc.subjectComplex structuresen_US
dc.subjectTabletsen_US
dc.subjectPatient-specificen_US
dc.subjectStructural designen_US
dc.title3D printed oral theophylline doses with innovative 'radiator-like' design: Impact of polyethylene oxide (PEO) molecular weighten_US
dc.status.refereedYesen_US
dc.date.Accepted2019-04-06
dc.date.application2019-04-08
dc.typeArticleen_US
dc.date.EndofEmbargo2020-04-09
dc.type.versionAccepted manuscripten_US
dc.description.publicnotesThe full-text of this article will be released for public view at the end of the publisher embargo on 09 Apr 2020.en_US
dc.date.updated2019-11-07T07:59:25Z
refterms.dateFOA2019-11-22T15:06:17Z


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