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dc.contributor.authorArafat, B.
dc.contributor.authorWojsz, M.
dc.contributor.authorIsreb, A.
dc.contributor.authorForbes, R.T.
dc.contributor.authorIsreb, Mohammad
dc.contributor.authorAhmed, W.
dc.contributor.authorArafat, T.
dc.contributor.authorAlhnan, M.A.
dc.date.accessioned2019-11-06T13:56:12Z
dc.date.accessioned2019-11-22T14:32:06Z
dc.date.available2019-11-06T13:56:12Z
dc.date.available2019-11-22T14:32:06Z
dc.date.issued2018-06-15
dc.identifier.citationArafat B, Wojsz M, Isreb A et al (2018) Tablet fragmentation without a disintegrant: A novel design approach for accelerating disintegration and drug release from 3D printed cellulosic tablets. European Journal of Pharmaceutical Sciences. 118: 191-199.en_US
dc.identifier.urihttp://hdl.handle.net/10454/17495
dc.descriptionYesen_US
dc.description.abstractFused deposition modelling (FDM) 3D printing has shown the most immediate potential for on-demand dose personalisation to suit particular patient's needs. However, FDM 3D printing often involves employing a relatively large molecular weight thermoplastic polymer and results in extended release pattern. It is therefore essential to fast-track drug release from the 3D printed objects. This work employed an innovative design approach of tablets with unique built-in gaps (Gaplets) with the aim of accelerating drug release. The novel tablet design is composed of 9 repeating units (blocks) connected with 3 bridges to allow the generation of 8 gaps. The impact of size of the block, the number of bridges and the spacing between different blocks was investigated. Increasing the inter-block space reduced mechanical resistance of the unit, however, tablets continued to meet pharmacopeial standards for friability. Upon introduction into gastric medium, the 1 mm spaces gaplet broke into mini-structures within 4 min and met the USP criteria of immediate release products (86.7% drug release at 30 min). Real-time ultraviolet (UV) imaging indicated that the cellulosic matrix expanded due to swelling of hydroxypropyl cellulose (HPC) upon introduction to the dissolution medium. This was followed by a steady erosion of the polymeric matrix at a rate of 8 μm/min. The design approach was more efficient than a comparison conventional formulation approach of adding disintegrants to accelerate tablet disintegration and drug release. This work provides a novel example where computer-aided design was instrumental at modifying the performance of solid dosage forms. Such an example may serve as the foundation for a new generation of dosage forms with complicated geometric structures to achieve functionality that is usually achieved by a sophisticated formulation approach.en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttps://doi.org/10.1016/j.ejps.2018.03.019en_US
dc.rights© 2018 Elsevier B.V. All rights reserved. . Reproduced in accordance with the publisher's self-archiving policy. This manuscript version is made available under the CC-BY-NC-ND 4.0 license.en_US
dc.subjectCelluloseen_US
dc.subjectPatient-centreden_US
dc.subjectBespokeen_US
dc.subjectPersonalizeden_US
dc.subjectGapleten_US
dc.subjectAdditive manufacturingen_US
dc.subjectComplex geometryen_US
dc.titleTablet fragmentation without a disintegrant: A novel design approach for accelerating disintegration and drug release from 3D printed cellulosic tabletsen_US
dc.status.refereedYesen_US
dc.date.Accepted2018-03-16
dc.date.application2018-03-17
dc.typeArticleen_US
dc.type.versionAccepted manuscripten_US
dc.date.updated2019-11-06T13:56:13Z
refterms.dateFOA2019-11-22T14:32:43Z


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