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dc.contributor.authorOsbak, K.K.
dc.contributor.authorVan Raemdonck, G.A.
dc.contributor.authorDom, M.
dc.contributor.authorCameron, C.E.
dc.contributor.authorMeehan, Conor J.
dc.contributor.authorDeforce, D.
dc.contributor.authorVan Ostade, X.
dc.contributor.authorKenyon, C.R.
dc.contributor.authorDhaenens, M.
dc.date.accessioned2019-11-05T13:24:44Z
dc.date.accessioned2019-11-21T15:40:08Z
dc.date.available2019-11-05T13:24:44Z
dc.date.available2019-11-21T15:40:08Z
dc.date.issued2018-10
dc.identifier.citationOsbak KK, Van Raemdonck GA, Dom M et al (2018) Candidate Treponema pallidum biomarkers uncovered in urine from individuals with syphilis using mass spectrometry. Future Microbiology. 13(13).en_US
dc.identifier.urihttp://hdl.handle.net/10454/17489
dc.descriptionNoen_US
dc.description.abstractAim: A diagnostic test that could detect Treponema pallidum antigens in urine would facilitate the prompt diagnosis of syphilis. Materials & methods: Urine from 54 individuals with various clinical stages of syphilis and 6 controls were pooled according to disease stage and interrogated with complementary mass spectrometry techniques to uncover potential syphilis biomarkers. Results & conclusion: In total, 26 unique peptides were uncovered corresponding to four unique T. pallidum proteins that have low genetic sequence similarity to other prokaryotes and human proteins. This is the first account of direct T. pallidum protein detection in human clinical samples using mass spectrometry. The implications of these findings for future diagnostic test development is discussed. Data are available via ProteomeXchange with identifier PXD009707.en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttps://doi.org/10.2217/fmb-2018-0182en_US
dc.subjectAntigen testen_US
dc.subjectBiomarker discoveryen_US
dc.subjectData-independent acquisitionen_US
dc.subjectMass spectrometryen_US
dc.subjectProteomicsen_US
dc.subjectSyphilisen_US
dc.subjectTreponema pallidumen_US
dc.subjectUrineen_US
dc.titleCandidate Treponema pallidum biomarkers uncovered in urine from individuals with syphilis using mass spectrometryen_US
dc.status.refereedYesen_US
dc.date.Accepted2018-07-30
dc.date.application2018-10-12
dc.typeArticleen_US
dc.type.versionNo full-text in the repositoryen_US
dc.date.updated2019-11-05T13:24:45Z


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