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    Candidate Treponema pallidum biomarkers uncovered in urine from individuals with syphilis using mass spectrometry

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    Publication date
    2018-10
    Author
    Osbak, K.K.
    Van Raemdonck, G.A.
    Dom, M.
    Cameron, C.E.
    Meehan, Conor J.
    Deforce, D.
    Van Ostade, X.
    Kenyon, C.R.
    Dhaenens, M.
    Keyword
    Antigen test
    Biomarker discovery
    Data-independent acquisition
    Mass spectrometry
    Proteomics
    Syphilis
    Treponema pallidum
    Urine
    Peer-Reviewed
    Yes
    
    Metadata
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    Abstract
    Aim: A diagnostic test that could detect Treponema pallidum antigens in urine would facilitate the prompt diagnosis of syphilis. Materials & methods: Urine from 54 individuals with various clinical stages of syphilis and 6 controls were pooled according to disease stage and interrogated with complementary mass spectrometry techniques to uncover potential syphilis biomarkers. Results & conclusion: In total, 26 unique peptides were uncovered corresponding to four unique T. pallidum proteins that have low genetic sequence similarity to other prokaryotes and human proteins. This is the first account of direct T. pallidum protein detection in human clinical samples using mass spectrometry. The implications of these findings for future diagnostic test development is discussed. Data are available via ProteomeXchange with identifier PXD009707.
    URI
    http://hdl.handle.net/10454/17489
    Version
    No full-text in the repository
    Citation
    Osbak KK, Van Raemdonck GA, Dom M et al (2018) Candidate Treponema pallidum biomarkers uncovered in urine from individuals with syphilis using mass spectrometry. Future Microbiology. 13(13).
    Link to publisher’s version
    https://doi.org/10.2217/fmb-2018-0182
    Type
    Article
    Collections
    Life Sciences Publications

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