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dc.contributor.authorSadia, M.
dc.contributor.authorIsreb, Abdullah
dc.contributor.authorAbbadi, I.
dc.contributor.authorIsreb, Mohammad
dc.contributor.authorAziz, D.
dc.contributor.authorSelo, A.
dc.contributor.authorTimmins, P.
dc.contributor.authorAlhnan, M.A.
dc.date.accessioned2019-11-07T07:58:12Z
dc.date.accessioned2019-11-07T08:24:41Z
dc.date.available2019-11-07T07:58:12Z
dc.date.available2019-11-07T08:24:41Z
dc.date.issued2018-10
dc.identifier.citationSadia M, Isreb A, Abbadi I, Isreb M et al (2018) From 'fixed dose combinations' to a 'dynamic dose combiner': 3D printed bi-layer antihypertensive tablets. European Journal Of Pharmaceutical Sciences. 123: 484-494.en_US
dc.identifier.urihttp://hdl.handle.net/10454/17413
dc.descriptionYesen_US
dc.description.abstractThere is an increased evidence for treating hypertension by a combination of two or more drugs. Increasing the number of daily intake of tablets has been reported to negatively affect the compliance of patients. Therefore, numerous fixed dose combinations (FDCs) have been introduced to the market. However, the inherent rigid nature of FDCs does not allow the titration of the dose of each single component for an individual patient's needs. In this work, flexible dose combinations of two anti-hypertensive drugs in a single bilayer tablet with a range of doses were fabricated using dual fused deposition modelling (FDM) 3D printer. Enalapril maleate (EM) and hydrochlorothiazide (HCT) loaded filaments were produced via hot-melt extrusion (HME). Computer software was utilised to design sets of oval bi-layer tablets of individualised doses. Thermal analysis and x-ray diffractometer (XRD) indicated that HCT remained crystalline in the polymeric matrix whilst EM appeared to be in an amorphous form. The interaction between anionic EM and cationic methacrylate polymer may have contributed to a drop in the glass transition temperature (Tg) of the filament and obviated the need for a plasticiser. Across all tablet sets, the methacrylate polymeric matrix provided immediate drug release profiles. This dynamic dosing system maintained the advantages of FDCs while providing a superior flexibility of dosing range, hence offering an optimal clinical solution to hypertension therapy in a patient-centric healthcare service.en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttps://doi.org/10.1016/j.ejps.2018.07.045en_US
dc.rights© 2018 Elsevier. Reproduced in accordance with the publisher's self-archiving policy.en_US
dc.subjectAdditive manufacturingen_US
dc.subjectFFFen_US
dc.subjectHigh blood pressureen_US
dc.subjectPatient-centreden_US
dc.subjectPolypharmacyen_US
dc.titleFrom ‘fixed dose combinations’ to ‘a dynamic dose combiner’: 3D printed bi-layer antihypertensive tabletsen_US
dc.status.refereedYesen_US
dc.date.Accepted2018-07-20
dc.date.application2018-07-21
dc.typeArticleen_US
dc.type.versionAccepted manuscripten_US
dc.date.updated2019-11-07T07:58:15Z
refterms.dateFOA2019-11-07T08:25:28Z


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