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    Structure Pharmaceutics Based on Synchrotron Radiation X-Ray Micro- Computed Tomography: From Characterization to Evaluation and Innovation of Pharmaceutical Structures

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    Author
    Yin, Xianzhen
    Supervisor
    York, Peter
    Shao, Qun
    Zhang, Jiwen
    Keyword
    Structure
    Synchroton radiation micro-computed tomography
    Three dimension
    Fractal dimension
    Quantitative characterisation
    Solid dosage form
    Pharmaceutics
    Rights
    Creative Commons License
    The University of Bradford theses are licenced under a Creative Commons Licence.
    Institution
    University of Bradford
    Department
    Faculty of Life Sciences
    Awarded
    2016
    
    Metadata
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    Abstract
    Drug delivery systems (DDS) are essentially pharmaceutical products for human therapy, typically involving a mixture of active ingredients and excipients. Based upon quantitative characterization of structure, the thesis introduces the concept of classifying the architecture of DDS into four levels by their spatial scale and the life time period. The primary level is recognised as the static structure of the whole dosage form with a size from μm to cm with the final structure generated by formulation design. The secondary level categorises the structures of particles or sub-units to form a DDS with sizes from nm to mm as key units in processing such as mixing, grinding, granulation and packing; The tertiary level represents the dynamic structures of DDS during the drug release phase in vitro or in vivo incorporating the structure size range from nm to mm, which undergo changes during dissolution, swelling, erosion or diffusion. The spatial scale for the quaternary level is defined as the meso or micro scale architecture of active and non-active molecules within a DDS with sizes from Å to μm for the molecular structure of drug and excipients. Methods combining X-ray tomography, image processing, and 3D reconstructions have been devised and evaluated to study systematically pharmaceutical structures and correlate them with drug release kinetics of DDS. Based on the quantitative structural information of pharmaceutical intermediates and dosage forms, it is possible now to correlate structures with production processing, behaviour and function, and the static and dynamic structures of DDS with the release kinetics. Thus, a structure-guided methodology has been established for the research of DDS.
    URI
    http://hdl.handle.net/10454/17378
    Type
    Thesis
    Qualification name
    PhD
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