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dc.contributor.authorRobles-Martinez, P.
dc.contributor.authorXu, X.
dc.contributor.authorTrenfield, S.J.
dc.contributor.authorAwad, A.
dc.contributor.authorGoyanes, A.
dc.contributor.authorTelford, Richard
dc.contributor.authorBasit, A.W.
dc.contributor.authorGaisford, S.
dc.date.accessioned2019-10-15T13:41:27Z
dc.date.accessioned2019-10-28T14:39:28Z
dc.date.available2019-10-15T13:41:27Z
dc.date.available2019-10-28T14:39:28Z
dc.date.issued2019-06
dc.identifier.citationRobles-Martinez P, Xu X, Trenfield SJ et al (2019) 3D Printing of a Multi-Layered Polypill Containing Six Drugs Using a Novel Stereolithographic Method. Pharmaceutics. 11(6): 274.
dc.identifier.urihttp://hdl.handle.net/10454/17370
dc.descriptionYes
dc.description.abstractThree-dimensional printing (3DP) has demonstrated great potential for multi-material fabrication because of its capability for printing bespoke and spatially separated material conformations. Such a concept could revolutionise the pharmaceutical industry, enabling the production of personalised, multi-layered drug products on demand. Here, we developed a novel stereolithographic (SLA) 3D printing method that, for the first time, can be used to fabricate multi-layer constructs (polypills) with variable drug content and/or shape. Using this technique, six drugs, including paracetamol, cffeine, naproxen, chloramphenicol, prednisolone and aspirin, were printed with dfferent geometries and material compositions. Drug distribution was visualised using Raman microscopy, which showed that whilst separate layers were successfully printed, several of the drugs diffused across the layers depending on their amorphous or crystalline phase. The printed constructs demonstrated excellent physical properties and the different material inclusions enabled distinct drug release profiles of the six actives within dissolution tests. For the first time, this paper demonstrates the feasibility of SLA printing as an innovative platform for multi-drug therapy production, facilitating a new era of personalised polypills.
dc.language.isoen
dc.rights© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
dc.subjectThree-dimensional printing
dc.subject3D printing
dc.subjectFixed-dose combinations
dc.subjectAdditive manufacturing
dc.subject3D printed drug products
dc.subjectPrintlets
dc.subjectTablets
dc.subjectPersonalized medicines
dc.subjectMultiple-layer dosage forms
dc.subjectStereolithography
dc.subjectVat polymerisation
dc.title3D Printing of a Multi-Layered Polypill Containing Six Drugs Using a Novel Stereolithographic Method
dc.status.refereedYes
dc.date.Accepted2019-06-03
dc.date.application2019-06-11
dc.typeArticle
dc.type.versionPublished version
dc.identifier.doihttps://doi.org/10.3390/pharmaceutics11060274
dc.rights.licenseCC-BY
dc.date.updated2019-10-15T12:41:40Z
refterms.dateFOA2019-10-28T14:46:14Z
dc.openaccess.statusopenAccess


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