Show simple item record

dc.contributor.authorRobles-Martinez, P.
dc.contributor.authorXu, X.
dc.contributor.authorTrenfield, S.J.
dc.contributor.authorAwad, A.
dc.contributor.authorGoyanes, A.
dc.contributor.authorTelford, Richard
dc.contributor.authorBasit, A.W.
dc.contributor.authorGaisford, S.
dc.date.accessioned2019-10-15T13:41:27Z
dc.date.accessioned2019-10-28T14:39:28Z
dc.date.available2019-10-15T13:41:27Z
dc.date.available2019-10-28T14:39:28Z
dc.date.issued2019-06
dc.identifier.citationRobles-Martinez P, Xu X, Trenfield SJ et al (2019) 3D Printing of a Multi-Layered Polypill Containing Six Drugs Using a Novel Stereolithographic Method. Pharmaceutics. 11(6): 274.en_US
dc.identifier.urihttp://hdl.handle.net/10454/17370
dc.descriptionYesen_US
dc.description.abstractThree-dimensional printing (3DP) has demonstrated great potential for multi-material fabrication because of its capability for printing bespoke and spatially separated material conformations. Such a concept could revolutionise the pharmaceutical industry, enabling the production of personalised, multi-layered drug products on demand. Here, we developed a novel stereolithographic (SLA) 3D printing method that, for the first time, can be used to fabricate multi-layer constructs (polypills) with variable drug content and/or shape. Using this technique, six drugs, including paracetamol, cffeine, naproxen, chloramphenicol, prednisolone and aspirin, were printed with dfferent geometries and material compositions. Drug distribution was visualised using Raman microscopy, which showed that whilst separate layers were successfully printed, several of the drugs diffused across the layers depending on their amorphous or crystalline phase. The printed constructs demonstrated excellent physical properties and the different material inclusions enabled distinct drug release profiles of the six actives within dissolution tests. For the first time, this paper demonstrates the feasibility of SLA printing as an innovative platform for multi-drug therapy production, facilitating a new era of personalised polypills.en_US
dc.language.isoenen_US
dc.rights© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).en_US
dc.subjectThree-dimensional printingen_US
dc.subject3D printingen_US
dc.subjectFixed-dose combinationsen_US
dc.subjectAdditive manufacturingen_US
dc.subject3D printed drug productsen_US
dc.subjectPrintletsen_US
dc.subjectTabletsen_US
dc.subjectPersonalized medicinesen_US
dc.subjectMultiple-layer dosage formsen_US
dc.subjectStereolithographyen_US
dc.subjectVat polymerisationen_US
dc.title3D Printing of a Multi-Layered Polypill Containing Six Drugs Using a Novel Stereolithographic Methoden_US
dc.status.refereedYesen_US
dc.date.Accepted2019-06-03
dc.date.application2019-06-11
dc.typeArticleen_US
dc.type.versionPublished versionen_US
dc.identifier.doihttps://doi.org/10.3390/pharmaceutics11060274
dc.date.updated2019-10-15T12:41:40Z
refterms.dateFOA2019-10-28T14:46:14Z


Item file(s)

Thumbnail
Name:
pharmaceutics-11-00274(3DPrint ...
Size:
3.589Mb
Format:
PDF

This item appears in the following Collection(s)

Show simple item record