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dc.contributor.authorAzmanova, Maria
dc.contributor.authorSoldevila-Barreda, Joan J.
dc.contributor.authorBani Hani, H.
dc.contributor.authorLord, Rianne M.
dc.contributor.authorPitto-Barry, Anaïs
dc.contributor.authorPicksley, Steven M.
dc.contributor.authorBarry, Nicolas P.E.
dc.date.accessioned2019-09-26T09:52:49Z
dc.date.accessioned2019-10-23T13:46:04Z
dc.date.available2019-09-26T09:52:49Z
dc.date.available2019-10-23T13:46:04Z
dc.date.issued2019-11-20
dc.identifier.citationAzmanova M, Soldevila-Barrera J, Bani Hani H et al (2019) Anticancer activity of electron-deficient metal complexes against colorectal cancer in vitro models. ChemMedChem. 14(22): 1887-1893.en_US
dc.identifier.urihttp://hdl.handle.net/10454/17321
dc.descriptionYesen_US
dc.description.abstractAn evaluation of the in vitro cytotoxicity of nine electron-deficient half-sandwich metal complexes towards two colorectal cancer cell lines (HCT116 p53+/+, HCT116 p53-/-) and one normal prostate cell line (PNT2) is presented herein. Three complexes were found to be equally cytotoxic towards both colorectal cancer cell lines, suggesting a p53-independent mechanism of action. These complexes are 12 to 34  more potent than cisplatin against HCT116 p53+/+ and HCT116 p53-/- cells. Furthermore, they were found to exhibit little or no cytotoxicity towards PNT2 normal cells, with selectivity ratios greater than 50. To gain an insight into the potential mechanisms of action of the most active compounds, their effects on the expression levels of a panel of genes were measured using qRT-PCR against treated HCT116 p53+/+ and HCT116 p53-/- cells, and cell cycle analysis was carried out.en_US
dc.description.sponsorshipThe Royal Society grant UF150295, The Academy of Medical Sciences grant SFB003\1170
dc.language.isoenen_US
dc.relation.isreferencedbyhttps://doi.org/10.1002/cmdc.201900528en_US
dc.rights(c) 2019 WileyVCH Verlag GmbH & Co. KGaA, Weinheim. This is the peer-reviewed version of the following article: Azmanova M, Soldevila-Barrera J, Bani Hani H et al (2019) Anticancer activity of electron-deficient metal complexes against colorectal cancer in vitro models' ChemMedChem. 14(22): 1887-1893, which has been published in final form at https://doi.org/10.1002/cmdc.201900528. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.en_US
dc.subjectColorectral canceren_US
dc.subjectElectron-deficienten_US
dc.subjectGene expressionen_US
dc.subjectHalf-sandwich complexesen_US
dc.subjectMetallodrugsen_US
dc.titleAnticancer activity of electron-deficient metal complexes against colorectal cancer in vitro modelsen_US
dc.status.refereedYesen_US
dc.date.Accepted2019-09-23
dc.date.application2019-09-23
dc.typeArticleen_US
dc.type.versionAccepted manuscripten_US
dc.date.updated2019-09-26T08:52:57Z
refterms.dateFOA2019-10-24T07:34:13Z


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