BRADFORD SCHOLARS

    • Sign in
    View Item 
    •   Bradford Scholars
    • Life Sciences
    • Life Sciences Publications
    • View Item
    •   Bradford Scholars
    • Life Sciences
    • Life Sciences Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of Bradford ScholarsCommunitiesAuthorsTitlesSubjectsPublication DateThis CollectionAuthorsTitlesSubjectsPublication Date

    My Account

    Sign in

    HELP

    Bradford Scholars FAQsCopyright Fact SheetPolicies Fact SheetDeposit Terms and ConditionsDigital Preservation Policy

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Anticancer activity of electron-deficient metal complexes against colorectal cancer in vitro models

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    View/Open
    cmdc.201900528_Script.docx (1.210Mb)
    Download
    Publication date
    2019-11-20
    Author
    Azmanova, Maria
    Soldevila-Barreda, Joan J.
    Bani Hani, H.
    Lord, Rianne M.
    Pitto-Barry, Anaïs
    Picksley, Steven M.
    Barry, Nicolas P.E.
    Keyword
    Colorectral cancer
    Electron-deficient
    Gene expression
    Half-sandwich complexes
    Metallodrugs
    Rights
    (c) 2019 WileyVCH Verlag GmbH & Co. KGaA, Weinheim. This is the peer-reviewed version of the following article: Azmanova M, Soldevila-Barrera J, Bani Hani H et al (2019) Anticancer activity of electron-deficient metal complexes against colorectal cancer in vitro models' ChemMedChem. 14(22): 1887-1893, which has been published in final form at https://doi.org/10.1002/cmdc.201900528. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
    Peer-Reviewed
    Yes
    
    Metadata
    Show full item record
    Abstract
    An evaluation of the in vitro cytotoxicity of nine electron-deficient half-sandwich metal complexes towards two colorectal cancer cell lines (HCT116 p53+/+, HCT116 p53-/-) and one normal prostate cell line (PNT2) is presented herein. Three complexes were found to be equally cytotoxic towards both colorectal cancer cell lines, suggesting a p53-independent mechanism of action. These complexes are 12 to 34  more potent than cisplatin against HCT116 p53+/+ and HCT116 p53-/- cells. Furthermore, they were found to exhibit little or no cytotoxicity towards PNT2 normal cells, with selectivity ratios greater than 50. To gain an insight into the potential mechanisms of action of the most active compounds, their effects on the expression levels of a panel of genes were measured using qRT-PCR against treated HCT116 p53+/+ and HCT116 p53-/- cells, and cell cycle analysis was carried out.
    URI
    http://hdl.handle.net/10454/17321
    Version
    Accepted manuscript
    Citation
    Azmanova M, Soldevila-Barrera J, Bani Hani H et al (2019) Anticancer activity of electron-deficient metal complexes against colorectal cancer in vitro models. ChemMedChem. 14(22): 1887-1893.
    Link to publisher’s version
    https://doi.org/10.1002/cmdc.201900528
    Type
    Article
    Collections
    Life Sciences Publications

    entitlement

     
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.