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    Genome-Wide SNP Analysis Reveals Distinct Origins of Trypanosoma evansi and Trypanosoma equiperdum.

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    Cuypers_trypOrigins_GBE_2017.pdf (381.4Kb)
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    Publication date
    2017-08
    Author
    Cuypers, B.
    Van den Broeck, F.
    Van Reet, N.
    Meehan, Conor J.
    Cauchard, J.
    Wilkes, J.M.
    Claes, F.
    Goddeeris, B.
    Birhanu, H.
    Dujardin, J.-C.
    Laukens, K.
    Büscher, P.
    Deborggraeve, S.
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    Keyword
    Trypanosoma evansi
    Trypansoma equiperdum
    Trypanozoon
    Whole genome sequencing
    SNP analysis
    Phylogeny
    Rights
    © The Author 2017. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
    Peer-Reviewed
    Yes
    
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    Abstract
    Trypanosomes cause a variety of diseases in man and domestic animals in Africa, Latin America, and Asia. In the Trypanozoon subgenus, Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense cause human African trypanosomiasis, whereas Trypanosoma brucei brucei, Trypanosoma evansi, and Trypanosoma equiperdum are responsible for nagana, surra, and dourine in domestic animals, respectively. The genetic relationships between T. evansi and T. equiperdum and other Trypanozoon species remain unclear because the majority of phylogenetic analyses has been based on only a few genes. In this study, we have conducted a phylogenetic analysis based on genome-wide SNP analysis comprising 56 genomes from the Trypanozoon subgenus. Our data reveal that T. equiperdum has emerged at least once in Eastern Africa and T. evansi at two independent occasions in Western Africa. The genomes within the T. equiperdum and T. evansi monophyletic clusters show extremely little variation, probably due to the clonal spread linked to the independence from tsetse flies for their transmission.
    URI
    http://hdl.handle.net/10454/17301
    Version
    Published version
    Citation
    Cuypers B, Van den Broeck F, Van Reet N, et al (2017) Genome-Wide SNP Analysis Reveals Distinct Origins of Trypanosoma evansi and Trypanosoma equiperdum' Genome Biology and Evolution. 9(8): 1990-1997.
    Link to publisher’s version
    https://doi.org/10.1093/gbe/evx102
    Type
    Article
    Collections
    Life Sciences Publications

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