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dc.contributor.authorDe Marco, M.
dc.contributor.authorClough, P.J.
dc.contributor.authorDyer, C.E.
dc.contributor.authorVince, R.V.
dc.contributor.authorWaby, Jennifer S.
dc.contributor.authorMidgley, A.W.
dc.contributor.authorVenneri, A.
dc.date.accessioned2019-10-10T16:18:27Z
dc.date.available2019-10-10T16:18:27Z
dc.date.issued2015-01
dc.identifier.citationDe Marco M, Clough PJ, Dyer CE et al (2015) Apolipoprotein E ε4 allele modulates the immediate impact of acute exercise on prefrontal function. Behavior Genetics. 45(1): 106-116.en_US
dc.identifier.urihttp://hdl.handle.net/10454/17299
dc.descriptionYesen_US
dc.description.abstractThe difference between Apolipoprotein E ε4 carriers and non-carriers in response to single exercise sessions was tested. Stroop and Posner tasks were administered to young untrained women immediately after walking sessions or moderately heavy exercise. Exercise had a significantly more profound impact on the Stroop effect than on the Posner effect, suggesting selective involvement of prefrontal function. A significant genotype-by-exercise interaction indicated differences in response to exercise between ε4 carriers and non-carriers. Carriers showed facilitation triggered by exercise. The transient executive down-regulation was construed as due to exercise-dependent hypofrontality. The facilitation observed in carriers was interpreted as better management of prefrontal metabolic resources, and explained within the antagonistic pleiotropy hypothesis framework. The findings have implications for the interpretation of differences between ε4 carriers and non-carriers in the benefits triggered by long-term exercise that might depend, at least partially, on mechanisms of metabolic response to physical activity.en_US
dc.description.sponsorshipPartially supported by a University of Hull Faculty of Science scholarship to MDM and by funding from MIUR and FP7 VPH-DARE to AV.en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttps://doi.org/10.1007/s10519-014-9675-5en_US
dc.rights© Springer Science+Business Media New York 2014. Reproduced in accordance with the publisher's self-archiving policy. The final publication is available at Springer via https://doi.org/10.1007/s10519-014-9675-5.en_US
dc.subjectPrefrontal cortexen_US
dc.subjectPhysiological responseen_US
dc.subjectStroop testen_US
dc.subjectPosner testen_US
dc.subjectAlzheimer's diseaseen_US
dc.titleApolipoprotein E ε4 allele modulates the immediate impact of acute exercise on prefrontal functionen_US
dc.status.refereedYesen_US
dc.date.Accepted2014-09-05
dc.date.application2014-09-14
dc.typeArticleen_US
dc.type.versionAccepted manuscripten_US
refterms.dateFOA2019-10-10T16:18:27Z


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