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    Apolipoprotein E ε4 allele modulates the immediate impact of acute exercise on prefrontal function

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    Waby_et_al_Behavior_Genetics.pdf (307.5Kb)
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    Publication date
    2015-01
    Author
    De Marco, M.
    Clough, P.J.
    Dyer, C.E.
    Vince, R.V.
    Waby, Jennifer S.
    Midgley, A.W.
    Venneri, A.
    Keyword
    Prefrontal cortex
    Physiological response
    Stroop test
    Posner test
    Alzheimer's disease
    Rights
    © Springer Science+Business Media New York 2014. Reproduced in accordance with the publisher's self-archiving policy. The final publication is available at Springer via https://doi.org/10.1007/s10519-014-9675-5.
    Peer-Reviewed
    Yes
    
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    Abstract
    The difference between Apolipoprotein E ε4 carriers and non-carriers in response to single exercise sessions was tested. Stroop and Posner tasks were administered to young untrained women immediately after walking sessions or moderately heavy exercise. Exercise had a significantly more profound impact on the Stroop effect than on the Posner effect, suggesting selective involvement of prefrontal function. A significant genotype-by-exercise interaction indicated differences in response to exercise between ε4 carriers and non-carriers. Carriers showed facilitation triggered by exercise. The transient executive down-regulation was construed as due to exercise-dependent hypofrontality. The facilitation observed in carriers was interpreted as better management of prefrontal metabolic resources, and explained within the antagonistic pleiotropy hypothesis framework. The findings have implications for the interpretation of differences between ε4 carriers and non-carriers in the benefits triggered by long-term exercise that might depend, at least partially, on mechanisms of metabolic response to physical activity.
    URI
    http://hdl.handle.net/10454/17299
    Version
    Accepted manuscript
    Citation
    De Marco M, Clough PJ, Dyer CE et al (2015) Apolipoprotein E ε4 allele modulates the immediate impact of acute exercise on prefrontal function. Behavior Genetics. 45(1): 106-116.
    Link to publisher’s version
    https://doi.org/10.1007/s10519-014-9675-5
    Type
    Article
    Collections
    Life Sciences Publications

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