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dc.contributor.authorLake, D.
dc.contributor.authorCorrêa, Sonia A.L.
dc.contributor.authorMüller, Jurgen
dc.date.accessioned2019-09-23T14:46:08Z
dc.date.accessioned2019-10-04T13:51:51Z
dc.date.available2019-09-23T14:46:08Z
dc.date.available2019-10-04T13:51:51Z
dc.date.issued2019-11-01
dc.identifier.citationLake D, Corrêa SAL and Muller J (2019) NMDA receptor-dependent signalling pathways regulate arginine vasopressin expression in the paraventricular nucleus of the rat. Brain Research. 1722: 146357.en_US
dc.identifier.urihttp://hdl.handle.net/10454/17287
dc.descriptionYesen_US
dc.description.abstractThe antidiuretic hormone arginine vasopressin (AVP) regulates water homeostasis, blood pressure and a range of stress responses. It is synthesized in the hypothalamus and released from the posterior pituitary into the general circulation upon a range of stimuli. While the mechanisms leading to AVP secretion have been widely investigated, the molecular mechanisms regulating AVP gene expression are mostly unclear. Here we investigated the neurotransmitters and signal transduction pathways that activate AVP gene expression in the paraventricular nucleus (PVN) of the rat using acute brain slices and quantitative real-time PCR. We show that stimulation with l-glutamate robustly induced AVP gene expression in acute hypothalamic brain slices containing the PVN. More specifically, we show that AVP transcription was stimulated by NMDA. Using pharmacological treatments, our data further reveal that the activation of ERK1/2 (PD184352), CaMKII (KN-62) and PI3K (LY294002; 740 Y-P) is involved in the NMDA-induced AVP gene expression in the PVN. Together, this study identifies NMDA-mediated cell signalling pathways that regulate AVP gene expression in the rat PVN.en_US
dc.description.sponsorshipSupported by a generous donation from Jonathan Feuer.en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttps://doi.org/10.1016/j.brainres.2019.146357en_US
dc.rights© 2019 Elsevier B.V. All rights reserved. Reproduced in accordance with the publisher's self-archiving policy. This manuscript version is made available under the CC-BY-NC-ND 4.0 license.en_US
dc.subjectArginine vasopressin (AVP)en_US
dc.subjectGlutamateen_US
dc.subjectNMDAen_US
dc.subjectGene expressionen_US
dc.subjectCell signallingen_US
dc.subjectMAPKen_US
dc.titleNMDA receptor-dependent signalling pathways regulate arginine vasopressin expression in the paraventricular nucleus of the raten_US
dc.status.refereedYesen_US
dc.date.Accepted2019-07-29
dc.date.application2019-07-29
dc.typeArticleen_US
dc.type.versionAccepted manuscripten_US
dc.date.updated2019-09-23T13:46:14Z
refterms.dateFOA2019-10-04T13:52:26Z


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