Show simple item record

dc.contributor.authorMadzivire, C.R.
dc.contributor.authorCarames-Mendez, P.
dc.contributor.authorPask, C.M.
dc.contributor.authorPhillips, Roger M.
dc.contributor.authorLord, Rianne M.
dc.contributor.authorMcGowan, P.C.
dc.date.accessioned2019-10-02T15:09:49Z
dc.date.available2019-10-02T15:09:49Z
dc.date.issued2019-12-01
dc.identifier.citationMadzivire CR, Carames-Mendez P, Pask CM et al (2019) Anticancer, antifungal and antibacterial potential of bis(β-ketoiminato)ruthenium(II) carbonyl complexes. Inorganica Chimica Acta. 498: 119025.en_US
dc.identifier.urihttp://hdl.handle.net/10454/17284
dc.descriptionNoen_US
dc.description.abstractHerein we report a library of new ruthenium(II) complexes which incorporate a range of functionalised β -ketoiminate ligands. The complexes undergo an unusual reduction from Ru(III) to Ru(II), and consequently incorporate carbonyl ligands from the 2-ethoxyethanol solvent, forming ruthenium dicarbonyl complexes. In order to address the potential applications of these complexes, we have screened the library against a range of tumour cell lines, however, all compounds exhibit low cellular activity and this is tentatively assigned to the decomposition of the compounds in aqueous media. Studies to establish the antifungal and antibacterial potential of these complexes was addressed and show increased growth inhibitions for C. neoformans and S. aureus species.en_US
dc.description.sponsorshipThe authors would like to thank the universities of Leeds, Huddersfield and Bradford for internal financial support.en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttps://doi.org/10.1016/j.ica.2019.119025en_US
dc.subjectAnticanceren_US
dc.subjectAntifungalen_US
dc.subjectAntibacteriaen_US
dc.subjectRutheniumen_US
dc.subjectBioinorganic chemistryen_US
dc.titleAnticancer, antifungal and antibacterial potential of bis(β-ketoiminato)ruthenium(II) carbonyl complexesen_US
dc.status.refereedYesen_US
dc.date.Accepted2019-07-17
dc.date.application2019-08-09
dc.typeArticleen_US
dc.type.versionNo full-text in the repositoryen_US
refterms.dateFOA2019-10-02T15:11:59Z


Item file(s)

Thumbnail
Name:
Lord_Pre-proof.docx
Size:
3.912Mb
Format:
Microsoft Word 2007
Description:
To keep suppressed

This item appears in the following Collection(s)

Show simple item record