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dc.contributor.authorBrocklesby, K.L.
dc.contributor.authorWaby, Jennifer S.
dc.contributor.authorCawthorne, C.
dc.contributor.authorSmith, G.
dc.date.accessioned2019-09-17T13:00:24Z
dc.date.accessioned2019-10-02T12:25:13Z
dc.date.available2019-09-17T13:00:24Z
dc.date.available2019-10-02T12:25:13Z
dc.date.issued2018-04-25
dc.identifier.citationBrocklesby KL, Waby JS, Cawthorne C and Smith G (2018) A practical microwave method for the synthesis of fluoromethy 4-methylbenzenesulfonate in tert-amyl alcohol. Tetrahedron Letters. 59(17): 1635-1637.en_US
dc.identifier.urihttp://hdl.handle.net/10454/17280
dc.descriptionYesen_US
dc.description.abstractFluorine substitution is an established tool in medicinal chemistry to favourably alter the molecular properties of a lead compound of interest. However, gaps still exist in the library of synthetic methods for accessing certain fluorine-substituted motifs. One such area is the fluoromethyl group, particularly when required in a fluoroalkylating capacity. The cold fluorination of methylene ditosylate is under evaluated in the literature, often proceeding with low yields or harsh conditions. This report describes a novel microwave method for the rapid nucleophilic fluorination of methylene ditosylate using inexpensive reagents in good isolated yield (65%).en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttps://doi.org/10.1016/j.tetlet.2018.03.039en_US
dc.rights(c) 2018 The Authors. This is an Open Access article distributed under the Creative Commons CC-BY license (http://creativecommons.org/licenses/by/4.0/)en_US
dc.subjectPETen_US
dc.subjectFluorinationen_US
dc.subjectMicrowaveen_US
dc.subjectFluoromethyl tosylateen_US
dc.subjectTert-amyl alcoholen_US
dc.titleA practical microwave method for the synthesis of fluoromethy 4-methylbenzenesulfonate in tert-amyl alcoholen_US
dc.status.refereedYesen_US
dc.date.Accepted2018-03-15
dc.date.application2018-03-16
dc.typeArticleen_US
dc.type.versionPublished versionen_US
dc.date.updated2019-09-17T12:00:28Z
refterms.dateFOA2019-10-02T12:25:36Z


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