A practical microwave method for the synthesis of fluoromethy 4-methylbenzenesulfonate in tert-amyl alcohol
dc.contributor.author | Brocklesby, K.L. | |
dc.contributor.author | Waby, Jennifer S. | |
dc.contributor.author | Cawthorne, C. | |
dc.contributor.author | Smith, G. | |
dc.date.accessioned | 2019-09-17T13:00:24Z | |
dc.date.accessioned | 2019-10-02T12:25:13Z | |
dc.date.available | 2019-09-17T13:00:24Z | |
dc.date.available | 2019-10-02T12:25:13Z | |
dc.date.issued | 2018-04-25 | |
dc.identifier.citation | Brocklesby KL, Waby JS, Cawthorne C and Smith G (2018) A practical microwave method for the synthesis of fluoromethy 4-methylbenzenesulfonate in tert-amyl alcohol. Tetrahedron Letters. 59(17): 1635-1637. | en_US |
dc.identifier.uri | http://hdl.handle.net/10454/17280 | |
dc.description | Yes | en_US |
dc.description.abstract | Fluorine substitution is an established tool in medicinal chemistry to favourably alter the molecular properties of a lead compound of interest. However, gaps still exist in the library of synthetic methods for accessing certain fluorine-substituted motifs. One such area is the fluoromethyl group, particularly when required in a fluoroalkylating capacity. The cold fluorination of methylene ditosylate is under evaluated in the literature, often proceeding with low yields or harsh conditions. This report describes a novel microwave method for the rapid nucleophilic fluorination of methylene ditosylate using inexpensive reagents in good isolated yield (65%). | en_US |
dc.language.iso | en | en_US |
dc.relation.isreferencedby | https://doi.org/10.1016/j.tetlet.2018.03.039 | en_US |
dc.rights | (c) 2018 The Authors. This is an Open Access article distributed under the Creative Commons CC-BY license (http://creativecommons.org/licenses/by/4.0/) | en_US |
dc.subject | PET | en_US |
dc.subject | Fluorination | en_US |
dc.subject | Microwave | en_US |
dc.subject | Fluoromethyl tosylate | en_US |
dc.subject | Tert-amyl alcohol | en_US |
dc.title | A practical microwave method for the synthesis of fluoromethy 4-methylbenzenesulfonate in tert-amyl alcohol | en_US |
dc.status.refereed | Yes | en_US |
dc.date.Accepted | 2018-03-15 | |
dc.date.application | 2018-03-16 | |
dc.type | Article | en_US |
dc.type.version | Published version | en_US |
dc.date.updated | 2019-09-17T12:00:28Z | |
refterms.dateFOA | 2019-10-02T12:25:36Z |